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Subunit: Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2. Component of a SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2. Interacts directly with CUL1 and SKP1. Interacts with CKS1. Interacts with the cyclin-A-CDK2 complex. Interacts with ORC1, phosphorylated CDT1, phosphorylated RBL2, ELF4, phosphorylated RAG2, FOXO1, UBP43, MYC, TOB1, TAL1 and KMT2A/MLL1. Interacts with TRIM21 Sequence caution: Sequence=AAC50242.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB87202.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for SKP2: 1FQV (3D) [IMAGE] 1FS1 (3D) [IMAGE] 1FS2 (3D) [IMAGE] 1LDK (3D) [IMAGE] 2ASS (3D) [IMAGE] 2AST (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: SKP2_HUMAN, Q13309 Function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration
Similarity: Contains 1 F-box domain Contains 10 LRR (leucine-rich) repeats [IMAGE]
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