TAG for SLC26A3

Gene content

Symbol

SLC26A3 ( by HUGO)

Name

Solute Carrier Family

Category

Tumor suppressor gene

Alias

Solute Carrier Family 26 (Anion Exchanger)
Member 3
DRA
CLD
Solute Carrier Family 26
Member 3
Congenital Chloride Diarrhea
Chloride Anion Exchanger
Down-Regulated In Adenoma Protein
Down-Regulated In Adenoma
Protein DRA
Solute Carrier Family 26 Member 3

Cytogenetic band

NCBI: 7q31 Ensembl: 7q31.1

Protein information

S26A3_HUMAN

Size: 764 amino acids

Mass: 84505 Da

Function:

UniProtKB/Swiss-Prot Summary: S26A3_HUMAN, P40879 Function: Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation

Similarity:

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family

Contains 1 STAS domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001902	SulP_transpt	Sulphate anion transporter	Family
	IPR002645	STAS_dom	Sulfate transporter/antisigma-factor antagonist STAS	Domain
	IPR011547	Sulph_transpt	Sulphate transporter	Domain
Blocks	IPB001902	Sulphate transporter	Sulphate transporter

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	anion transport	TAS	GOA	9554749
	excretion	TAS	GOA	8896562
	regulation of transcription, DNA-templated	TAS	GOA	7683425
Molecular Function	protein binding	IPI	GOA	12369822
	sequence-specific DNA binding transcription factor activity	TAS	GOA	7683425
	transcription cofactor activity	TAS	GOA	7683425
	transporter activity	TAS	GOA	8896562

Disorder & Mutation
Source	Disease
SWISS-PROT	Diarrhea 1, secretory chloride, congenital (DIAR1) [MIM:214700]: A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. Note=The disease is caused by mutations affecting the gene represented in this entry

SLC26A3 cross reference