Gene content  |
| SLC6A4 (-- by HUGO) |
| solute carrier family 6 (neurotransmitter transporter, serotonin),... ------------------------------ |
| -- |
| Solute Carrier Family 6 (Neurotransmitter Transporter, Serotonin),Member4OCD1HTT5-HTTLPR5-HTT5-Hydroxytryptamine TransporterSERT1HSERT5HTTNa+/Cl- Dependent Serotonin Transporter5HT TransporterSodium-Dependent Serotonin TransporterSERTSolute Carrier Family 6 Member |
| NCBI: 17q11.2 Ensembl: 17q11.2 |
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Subcellular location: Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the pl
Subunit: Monomer or homooligomer (By similarity). Interacts with TGFB1I1. Interacts (via sialylated form) with MYH9. Interacts with SEC23A, SEC24C and INADL. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with VIM. Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly. Interacts with RAB4 (GTP-bound form); the interaction retains transporter molecules intracellularly
Tissue specificity: Expressed in platelets (at protein level)
Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily
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