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Function: UniProtKB/Swiss-Prot Summary: SMO_HUMAN, Q99835 Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia Gene Ontology (GO): Selected molecular function terms (see all 8): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004888 transmembrane signaling receptor activity -- -- GO:0004930 G-protein coupled receptor activity IEA -- GO:0005113 patched binding IPI 9811851 GO:0005515 protein binding IPI 19592253 GO:0008144 drug binding IDA 19304771 [IMAGE] Find genes that share ontologies with SMO About GenesLikeMe Phenotypes: 3 GenomeRNAi human phenotypes for SMO: Decreased Wnt reporter activit Increased G1 DNA content Synthetic lethal with paclitax Selected MGI mutant phenotypes (inferred from 5 alleles[IMAGE]) (MGI details for Smo) (see all 16): cardiovascular system cellular craniofacial digestive/alimentary embryogenesis growth/size/body hearing/vestibular/ear homeostasis/metabolism limbs/digits/tail mortality/aging muscle nervous system normal respiratory system skeleton [IMAGE] Find genes that share phenotypes with SMO About GenesLikeMe Animal Models: MGI mouse knock-outs for SMO: Smotm1Amc Smotm2.1Amc Smotm1.1Pab [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SMO [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SMO [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SMO [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SMO miRNA Products: miRTarBase miRNAs that target SMO: hsa-mir-326 (MIRT000526), hsa-mir-324-5p (MIRT000527), hsa-mir-338-3p (MIRT006455), hsa-mir-125b-5p (MIRT000525), hsa-mir-331-3p (MIRT043390) [IMAGE] Block miRNA regulation of human, mouse, rat SMO using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate SMO (see all 10): hsa-miR-300 hsa-miR-381 hsa-miR-188-3p hsa-miR-1270 hsa-miR-370 hsa-miR-620 hsa-miR-127-5p hsa-miR-1252 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: SMO 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for SMO [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat SMO Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for SMO Clone Products: [IMAGE] OriGene clones in human, mouse for SMO (see all 8) OriGene ORF clones in mouse, rat for SMO OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: SMO (NM_005631) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for SMO [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SMO [IMAGE] Addgene plasmids for SMO [IMAGE] Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for SMO [IMAGE] ESI BIO PureStem Progenitor for SMO: [IMAGE] PureStem 7SMOO32, NCr-fac & Meso Progenitor In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SMO
Similarity: Belongs to the G-protein coupled receptor Fz/Smo family Contains 1 FZ (frizzled) domain [IMAGE]
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