Gene content    
SNCG ( by HUGO)
Synuclein, Gamma (Breast Cancer-Specific Protein 1)
Other
Synuclein
Gamma (Breast Cancer-Specific Protein 1)
BCSG1
synoretin
Breast Cancer-Specific Gene 1 Protein
SR
gamma-synuclein
persyn
PERSYN
PRSN
Persyn
Synoretin
NCBI: 10q23.2-q23.3    Ensembl: 10q23.2
SYUG_HUMANSize: 127 amino acidsMass: 13331 Da

  • Subunit: May be a centrosome-associated protein
  • Tissue specificity: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung [IMAGE] Custom PCR Arrays for SNCG Primer Product
  • Function:
    UniProtKB/Swiss-Prot Summary: SYUG_HUMAN, O76070 Function: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)
  • Similarity:
    Belongs to the synuclein family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001058SynucleinSynucleinFamily
    IPR002462Synuclein_gammaGamma-synucleinFamily
    BlocksIPB001058Synuclein signatureSynuclein signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Cellular Component cytoplasm IDA GOA 17222866
    extracellular vesicular exosome IDA GOA 19056867

    SNCG cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene