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Subunit: Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP Miscellaneous: Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for SPHK1: 3VZB (3D) [IMAGE] 3VZC (3D) [IMAGE] 3VZD (3D) [IMAGE] 4L02 (3D) [IMAGE]
Tissue specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including SPHK1: Hypertension in human mouse rat Endothelial Cell Biology in human mouse rat VEGF Signaling in
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol Catalytic activity: ATP + sphinganine = ADP + sphinganine 1-phosphate Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol
Catalytic activity: ATP + sphinganine = ADP + sphinganine 1-phosphate ATP + sphingosine = ADP + sphingosine 1-phosphate Biophysicochemical properties: Kinetic parameters: KM=14 uM for sphingosine; KM=20 uM for dihydrosphingosine; KM=77 uM for ATP; pH dependence: Optimum pH is 7.4;
Similarity: Contains 1 DAGKc domain [IMAGE]
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