Gene content
Symbol	SPINT2 ( by HUGO)
Name	Serine Peptidase Inhibitor, Kunitz Type,
Category	Tumor suppressor gene
Alias	Serine Peptidase Inhibitor Kunitz Type 2 Placental Bikunin HAI2 Serine Protease Inhibitor Kunitz Type 2 Hepatocyte Growth Factor Activator Inhibitor Type 2 HAI-2 DIAR3 Kop PB Kunitz-Type Protease Inhibitor 2 KOP
Cytogenetic band	NCBI: 19q13.1    Ensembl: 19q13.2
Protein information	SPIT2_HUMAN Size: 252 amino acids Mass: 28228 Da Tissue specificity: Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea [IMAGE] Custom PCR Arrays for SPINT2 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for SPINT2 OriGene qSTAR qPCR primer pairs in human, mouse for SP Function: UniProtKB/Swiss-Prot Summary: SPIT2_HUMAN, O43291 Function: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa Similarity: Contains 2 BPTI/Kunitz inhibitor domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR002223	Prot_inh_Kunz-m	Proteinase inhibitor I2, Kunitz metazoa	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cellular component movement	TAS	GOA	9434156
	negative regulation of endopeptidase activity	TAS	GOA	9115294
Cellular Component	cytoplasm	IDA	GOA	11606055
	extracellular region	TAS	GOA	9346890
Molecular Function	endopeptidase inhibitor activity	TAS	GOA	9115294

Disorder & Mutation
Source	Disease
SWISS-PROT	Diarrhea 3, secretory sodium, congenital (DIAR3) [MIM:270420]: A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes. Note=The disease is caused by mutations affecting the gene represented in this entry

SPINT2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene