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Subunit: Forms homooligomers (By similarity). Interacts with PLAUR (via the UPAR/Ly6 domains), ADAMTS4 and CTSB. Interacts with HGF; the interaction increases the mitogenic activity of HGF
Tissue specificity: Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed
Function: UniProtKB/Swiss-Prot Summary: SRPX2_HUMAN, O60687 Function: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development Gene Ontology (GO): 4 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005102 receptor binding IPI 18718938 GO:0005515 protein binding IPI 18718938 GO:0036458 hepatocyte growth factor binding IDA -- GO:0042802 identical protein binding IDA -- [IMAGE] Find genes that share ontologies with SRPX2 About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRPX2 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRPX2 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRPX2 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRPX2 miRNA Products: [IMAGE] Block miRNA regulation of human, mouse, rat SRPX2 using miScript Target Protectors [IMAGE] 4 qRT-PCR Assays for microRNAs that regulate SRPX2: hsa-miR-875-3p hsa-miR-149 hsa-miR-3116 hsa-miR-651 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: SRPX2 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for SRPX2 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat SRPX2 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for SRPX2 Clone Products: [IMAGE] OriGene clones in human, mouse for SRPX2 (see all 8) OriGene ORF clones in mouse, rat for SRPX2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: SRPX2 (NM_014467) [IMAGE] Sino Biological Human cDNA Clone for SRPX2 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRPX2 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRPX2 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for SRPX2 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for SRPX2 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRPX2
Similarity: Contains 1 HYR domain Contains 3 Sushi (CCP/SCR) domains [IMAGE]
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