Gene content    
SSTR3 ( by HUGO)
Somatostatin Receptor 3
Other
Somatostatin Receptor 3
SS-3-R
SS3-R
SS3R
SSR-28
Somatostatin Receptor Type 3
NCBI: 22q13.1    Ensembl: 22q13.1
SSR3_HUMANSize: 418 amino acidsMass: 45847 Da

  • Subunit: Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity)
  • Tissue specificity: Brain, pituitary and pancreas [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR3: G Protein Coupled Receptors 384HT in human mouse rat Primary Cilia in human mouse rat Apoptosis 384HT in human mouse rat Primer Products: [IMAGE] OriG
  • Function:
    UniProtKB/Swiss-Prot Summary: SSR3_HUMAN, P32745 Function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase
  • Similarity:
    Belongs to the G-protein coupled receptor 1 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000276GPCR_RhodpsnRhodopsin-like GPCR superfamilyFamily
    IPR000586Somatstn_rcptSomatostatin receptorFamily
    IPR001856Somatstn_rcpt_3Somatostatin receptor, type 3Family
    BlocksIPB000586Somatostatin receptor signatureSomatostatin receptor signature
    IPB001856Somatostatin receptor type 3 signatureSomatostatin receptor type 3 signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell-cell signaling TAS GOA 1337145
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS GOA 8405411
    hormone-mediated apoptotic signaling pathway TAS GOA 8961277
    negative regulation of cell proliferation TAS GOA 8961277
    Cellular Component integral component of plasma membrane TAS GOA 1337145
    Molecular Function protein binding IPI GOA 19071123

    SSTR3 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene