Gene content  |
| ST13 ( by HUGO) |
| Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp7... |
| Tumor suppressor gene |
| Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) Progesterone Receptor-Associated P48 Protein Aging-Associated Protein 2 Putative Tumor Suppressor ST13 Renal Carcinoma Antigen NY-REN-33 Suppression Of Tumorigenicity 13 Protein AAG2 FAM10A1 HIP SNC6 HOP P48 Suppression Of Tumorigenicity 13 (Colon Carcinoma) (Hsp70-Interacting Protein) FAM10A4 HSPABP HSPABP1 PRO0786 Heat Shock 70kD Protein Binding Protein Hsc70-Interacting Protein Hsp70-Interacting Protein Hip Protein FAM10A1 |
| NCBI: 22q13.2 Ensembl: 22q13.2 |
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Subunit: Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90 (By similarity). Interacts (via the C-terminus 303- 319 AA) with GRK5 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for ST13: 1UZS (3D) [IMAGE]
Function: UniProtKB/Swiss-Prot Summary: F10A1_HUMAN, P50502 Function: One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)
Similarity: Belongs to the FAM10 family Contains 1 STI1 domain Contains 3 TPR repeats [IMAGE]
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