Gene content
Symbol	STEAP3 ( by HUGO)
Name	STEAP Family Member 3, Metalloreductase
Category	Tumor suppressor gene
Alias	STEAP Family Member 3 Metalloreductase TSAP6 Six-Transmembrane Epithelial Antigen Of Prostate 3 Tumor Suppressor-Activated Pathway Protein 6 hTSAP6 hpHyde pHyde AHMIO2 1010001D01Rik STMP3 Dudlin 2 dudlin-2 Dudulin 2 dudulin-2 Metalloreductase STEAP3 Six Transmembrane Prostate Protein 3 Tumor Suppressor PHyde Dudulin-2 EC 1.16.1.-
Cytogenetic band	NCBI: 2q14.2    Ensembl: 2q14.2
Protein information	STEA3_HUMAN Size: 488 amino acids Mass: 54601 Da Subunit: Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP Caution: Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033) 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for STEAP3: 2VNS (3D) [IMAGE] 2VQ3 (3D) [IMAGE] Tissue specificity: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma [IMAGE] Custom PCR Arrays for STEAP3 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for STEAP3 OriGene qST Function: UniProtKB/Swiss-Prot Summary: STEA3_HUMAN, Q658P3 Function: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP Similarity: Belongs to the STEAP family                        Contains 1 ferric oxidoreductase domain [IMAGE]

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	protein secretion	IDA	GOA	15319436
Cellular Component	multivesicular body	IDA	GOA	15319436

Disorder & Mutation
Source	Disease
SWISS-PROT	Anemia, hypochromic microcytic, with iron overload 2 (AHMIO2) [MIM:615234]: A hematologic disease characterized by abnormal hemoglobin content in the erythrocytes which are reduced in size, severe anemia, erythropoietic hyperplasia of bone marrow, massive hepatic iron deposition, and hepatosplenomegaly. Note=The disease is caused by mutations affecting the gene represented in this entry

STEAP3 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene