Gene content    
STK6 (approved by HUGO)
serine/threonine kinase 6
Other
EC 2.7.1.37
AIK
ARK1
AURA
Aurora-A
BTAK
MGC34538
STK15
hARK1
NCBI: 20q13.2-q13.3    Ensembl: 20q13.31
STK6_HUMANSize: 403 amino acidsMass: 45809 Da

  • Subcellular location: Localizes on centrosomes in interphase cells and at each spindle pole in mitosis
  • Subunit: Interacts with TACC1
  • Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines. Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M,
  • Function:
    May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Maybe involved in microtubule formation and/or stabilization. May play a key role during tumor development and progression
  • Catalytic activity:
    ATP + a protein = ADP + a phosphoprotein
  • Similarity:
    Belongs to the Ser/Thr protein kinase family. Aurora subfamily

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000719Prot_kinaseProtein kinaseDomain
    IPR002290Ser_thr_pkinaseSerine/threonine protein kinaseDomain
    IPR008271Ser_thr_pkin_ASSerine/threonine protein kinase, active siteActive Sites

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process ATP binding IEA GOA
    cell cycle NAS GOA PubMed
    nucleus TAS GOA PubMed
    protein binding IPI GOA PubMed
    protein binding IDA GOA PubMed
    protein kinase activity IEA GOA
    protein serine/threonine kinase activity IEA GOA
    regulation of protein stability IMP GOA PubMed
    spindle TAS GOA PubMed
    spindle organization and biogenesis NAS GOA PubMed
    transferase activity IEA GOA
    Cellular Component nucleotide binding IEA GOA
    Molecular Function mitosis TAS GOA PubMed
    phosphoinositide-mediated signaling NAS GOA PubMed
    protein amino acid phosphorylation IEA GOA
    protein amino acid phosphorylation TAS GOA PubMed

    STK6 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene