Gene content    
TACC1 ( by HUGO)
Transforming, Acidic Coiled-Coil Containing Protein 1
Other
Transforming
Acidic Coiled-Coil Containing Protein 1
Gastric Cancer Antigen Ga55
Ga55
taxin-1
Transforming Acidic Coiled-Coil-Containing Protein 1
KIAA1103
Taxin-1
NCBI: 8p11.22    Ensembl: 8p11.22
TACC1_HUMANSize: 805 amino acidsMass: 87794 Da

  • Subunit: Interacts with KIAA0097/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with AURKA, AURKB and AURKC. Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF Developmental stage: Expressed at high level during early embryogenesis
  • Tissue specificity: Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gast
  • Function:
    UniProtKB/Swiss-Prot Summary: TACC1_HUMAN, O75410 Function: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues
  • Similarity:
    Belongs to the TACC family
                          
    Contains 2 SPAZ (Ser/Pro-rich AZU-1) domains [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007707TACCTransforming acidic coiled-coil-containingFamily
    BlocksIPB007707Transforming acidic coiled-coil-containingTransforming acidic coiled-coil-containing

    Gene Ontology    
    Type Term Evidence Source Pub
    Molecular Function protein binding IPI GOA 11903063

    TACC1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene