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Subunit: Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF Developmental stage: Expressed in fetal brain, lung, liver and kidney Sequence caution: Sequence=AAF29537.2; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAF63433.1; Type=Erroneous initiation;
Tissue specificity: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea [IMAGE] Custom PCR Arrays for TACC2 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for TACC2 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human,
Function: UniProtKB/Swiss-Prot Summary: TACC2_HUMAN, O95359 Function: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker Enzyme Numbers (IUBMB): EC 4.3.2.12 EC 2.4.2.102 EC 6.3.5.22 Gene Ontology (GO): 2 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0019904 protein domain specific binding IEA -- GO:0035257 nuclear hormone receptor binding IDA 15207008 [IMAGE] Find genes that share ontologies with TACC2 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for TACC2: Decreased G3BP1 protein expres Increased HPV18 LCR reporter a
Similarity: Belongs to the TACC family Contains 1 SPAZ (Ser/Pro-rich AZU-1) domain [IMAGE]
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