TAG for TAL1

Gene content

Symbol

TAL1 ( by HUGO)

Name

T-Cell Acute Lymphocytic Leukemia 1

Category

Oncogene

Alias

T-Cell Acute Lymphocytic Leukemia 1
TCL5
SCL
Class A Basic Helix-Loop-Helix Protein 17
Stem Cell Protein
bHLHa17
T-Cell Leukemia/Lymphoma Protein 5
T-Cell Acute Lymphocytic Leukemia Protein 1
tal-1
Tal-1 Product
BHLHA17
TAL-1

Cytogenetic band

NCBI: 1p32 Ensembl: 1p33

Protein information

TAL1_HUMAN

Size: 331 amino acids

Mass: 34271 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity) 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for TAL1: 2YPA (3D) [IMAGE] 2YPB (3D) [IMAGE]

Tissue specificity: Leukemic stem cell [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including TAL1: Leukemia in human mouse rat Hematopoiesis in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for TAL1 OriGene qSTAR qPCR

Function:

UniProtKB/Swiss-Prot Summary: TAL1_HUMAN, P17542 Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) Gene Ontology (GO): Selected molecular function terms (see all 14): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0000976 transcription regulatory region sequence-specific DNA binding -- -- GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA -- GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IEA -- GO:0001085 RNA polymerase II transcription factor binding IPI 15920471 GO:0003677 DNA binding -- -- [IMAGE] Find genes that share ontologies with TAL1 About GenesLikeMe Phenotypes:

Similarity:

Contains 1 bHLH (basic helix-loop-helix) domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR011598	bHLH_dom	Helix-loop-helix DNA-binding	Domain
Blocks	IPB001092	Basic helix-loop-helix dimerization domain bHLH	Basic helix-loop-helix dimerization domain bHLH

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	basophil differentiation	IEP	GOA	7678994
	erythrocyte differentiation	IMP	GOA	1396592
	erythrocyte differentiation	IEP	GOA	7678994
	megakaryocyte differentiation	IEP	GOA	7678994
Cellular Component	colocalizes_with histone deacetylase complex	IDA	GOA	19497860
	colocalizes_with Lsd1/2 complex	IDA	GOA	19497860
	nucleus	IDA	GOA	19497860
	transcription factor complex	IDA	GOA	15920471
Molecular Function	chromatin binding	IDA	GOA	16763211
	enzyme binding	IPI	GOA	19497860
	histone deacetylase binding	IPI	GOA	19497860
	protein binding	IPI	GOA	19497860
	RNA polymerase II transcription factor binding	IPI	GOA	15920471
	sequence-specific DNA binding transcription factor activity	IDA	GOA	19497860

Disorder & Mutation
Source	Disease
Genatlas	acute lymphoblastic leukemia (T cell) with interstitial deletion 5' to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA
SWISS-PROT	Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes

TAL1 cross reference