Gene content    
TCL1A ( by HUGO)
T-Cell Leukemia/Lymphoma 1A
Oncogene
T-Cell Leukemia/Lymphoma 1A
TCL1
Oncogene TCL-1
Oncogene TCL1
Protein P14 TCL1
T-Cell Leukemia/Lymphoma Protein 1A
T-Cell Lymphoma-1
NCBI: 14q32.1    Ensembl: 14q32.13
TCL1A_HUMANSize: 114 amino acidsMass: 13460 Da

  • Subunit: Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for TCL1A: 1JSG (3D) [IMAGE]
  • Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including TCL1A: PI3K-AKT Signalin
  • Function:
    UniProtKB/Swiss-Prot Summary: TCL1A_HUMAN, P56279 Function: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival
  • Similarity:
    Belongs to the TCL1 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR004832TCL1_MTCP1TCL1/MTCP1Family
    BlocksIPB004832TCL1/MTCP1 familyTCL1/MTCP1 family

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process multicellular organismal development TAS GOA 7809072
    Molecular Function protein binding IPI GOA 16934922

    Disorder & Mutation    
    Source Disease
    Genatlaschronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations t(14;14)(q11;q32),t(7;14)(q35;q32)
    SWISS-PROTNote=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci

    TCL1A cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene