Gene content
Symbol	TFAP2C ( by HUGO)
Name	Transcription Factor AP-2 Gamma (Activating Enhancer Binding...
Category	Other
Alias	Transcription Factor AP-2 Gamma (Activating Enhancer Binding Protein 2 Gamma) Transcription Factor AP-2 Gamma (Activating Enhancer-Binding Protein 2 Gamma) Estrogen Receptor Factor 1 Activating Enhancer-Binding Protein 2 Gamma Transcription Factor ERF-1 AP2-GAMMA ERF1 TFAP2G hAP-2g Transcription Factor AP-2 Gamma AP2-gamma
Cytogenetic band	NCBI: 20q13.2    Ensembl: 20q13.31
Protein information	AP2C_HUMAN Size: 450 amino acids Mass: 49177 Da Subunit: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity Function: UniProtKB/Swiss-Prot Summary: AP2C_HUMAN, Q92754 Function: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC Similarity: Belongs to the AP-2 family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR004979	TF_AP2	Transcription factor AP-2	Family
	IPR008123	TF_AP2_gamma	Transcription factor AP-2 gamma	Family
Blocks	IPB004979	Transcription factor AP-2 signature	Transcription factor AP-2 signature
	IPB008123	Transcription factor AP-2 gamma signature	Transcription factor AP-2 gamma signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell-cell signaling	TAS	GOA	9113991
	male gonad development	IEP	GOA	17848411
	negative regulation of transcription from RNA polymerase II promoter	IDA	GOA	11278550
	regulation of transcription from RNA polymerase II promoter	TAS	GOA	9113991
Molecular Function	DNA binding	IDA	GOA	12072434
	protein binding	IPI	GOA	11694877
	protein dimerization activity	IDA	GOA	12072434
	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA	GOA	11278550
	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	GOA	11278550
	sequence-specific DNA binding transcription factor activity	TAS	GOA	9113991

TFAP2C cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene