Gene content    
TFG ( by HUGO)
TRK-Fused Gene
Oncogene
TRK-Fused Gene
TRK-Fused Gene Protein
HMSNP
SPG57
TF6
TRKT3
Protein TFG
TRKT3 Oncogene
NCBI: 3q12.2    Ensembl: 3q12.2
TFG_HUMANSize: 400 amino acidsMass: 43448 Da

  • Tissue specificity: Ubiquitous [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including TFG: Neurotrophins & Receptors in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for TFG OriGene qSTAR qPCR primer pairs in human, mou
  • Function:
    Genatlas biochemistry entry for TFG: TRK fused gene,involved in chromosomal rearrangement involving TRKA(NTRK1),in papillary thyroid carcinoma Gene Ontology (GO): 3 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0004871 signal transducer activity IMP 12761501 GO:0005515 protein binding IPI 16189514 GO:0042802 identical protein binding IEA -- [IMAGE] Find genes that share ontologies with TFG About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for TFG: Decreased BPV1 E2 protein expr Increased HPV18 LCR reporter a 1 MGI phenotypic allele [IMAGE] for Tfg (no phenotypes) [IMAGE] Find genes that share phenotypes with TFG About GenesLikeMe Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TFG [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TFG [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TFG [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TFG miRNA Products: miRTarBase miRNAs that target TFG: hsa-mir-106a-5p (MIRT048315), hsa-mir-192-5p (MIRT004131), hsa-mir-193b-3p (MIRT041287), hsa-mir-877-3p (MIRT036854), hsa-mir-92a-3p (MIRT049807) [IMAGE] Block miRNA regulation of human, mouse, rat TFG using miScript Target Protectors [IMAGE] 6 qRT-PCR Assays for microRNAs that regulate TFG: hsa-miR-142-3p hsa-miR-133a hsa-miR-889 hsa-miR-4255 hsa-miR-133b hsa-miR-4294 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: TFG 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for TFG [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat TFG Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for TFG Clone Products: [IMAGE] OriGene clones in human, mouse for TFG (see all 16) OriGene ORF clones in mouse, rat for TFG OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 4): TFG (NM_001007565) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for TFG [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TFG Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for TFG [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for TFG [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TFG

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000270OPR_PB1Octicosapeptide/Phox/Bem1pDomain

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling IMP GOA 12761501
    signal transduction IMP GOA 12761501
    Cellular Component cytoplasm NAS GOA 7565764
    Molecular Function protein binding IPI GOA 16189514
    signal transducer activity IMP GOA 12761501

    Disorder & Mutation    
    Source Disease
    SWISS-PROTThyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript
    SWISS-PROTHereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis. Note=The disease is caused by mutations affecting the gene represented in this entry

    TFG cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene