Gene content  |
| TGFB1 ( by HUGO) |
| Transforming Growth Factor, Beta 1 |
| Oncogene & -- |
| Transforming Growth Factor Beta 1 TGFB DPD1 Prepro-Transforming Growth Factor Beta-1 TGF-beta-1 CED Camurati-Engelmann Disease LAP TGFbeta Latency-Associated Peptide Transforming Growth Factor Beta-1 |
| NCBI: 19q13.1 Ensembl: 19q13.2 |
|
Subunit: Homodimer; disulfide-linked, or heterodimer with TGFB2 (By similarity). Secreted and stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide (LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1 complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3 (By similarity). May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition (By similarity). Latency-associated peptide interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction (By similarity). Interacts with CD109, DPT and ASPN 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for TGFB1: 1KLA (3D) [IMAGE] 1KLC (3D) [IMAGE] 1KLD (3D) [IMAGE] 3KFD (3D) [IMAGE]
Tissue specificity: Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage [IMAGE] Pathway & Disease-focused RT2 Profiler P
Function: UniProtKB/Swiss-Prot Summary: TGFB1_HUMAN, P01137 Function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts
Similarity: Belongs to the TGF-beta family [IMAGE]
|
| Protein Domain/Family |
| Source |
ID |
Domain |
Name |
Type |
| InterPro | IPR001111 | TGF-b_N | Transforming growth factor beta (TGFb), N-terminal | Domain
|
| IPR001839 | TGF-b_C | Transforming growth factor beta | Domain
|
| IPR003939 | TGFb1 | Transforming growth factor, beta 1 | Family
|
| Blocks | IPB001111 | Transforming growth factor beta (TGFb) | Transforming growth factor beta (TGFb), N-terminal |
| IPB001111 | Transforming growth factor beta (TGFb) | Transforming growth factor beta (TGFb), N-terminal |
| IPB001111 | Transforming growth factor beta (TGFb) | Transforming growth factor beta (TGFb), N-terminal |
| IPB001111 | Transforming growth factor beta (TGFb) IPB001839 Transforming growth factor beta (TGFb) IPB003939 Transforming growth factor beta 1 precursor signature | Transforming growth factor beta (TGFb), N-terminal |
| IPB002400 | Growth factor cystine knot superfamily signature | Growth factor cystine knot superfamily signature |
| IPB003911 | Transforming growth factor beta precursor signature | Transforming growth factor beta precursor signature |
