TAG for TGFBR3

Gene content

Symbol

TGFBR3 ( by HUGO)

Name

Transforming Growth Factor, Beta Receptor III

Category

Tumor suppressor gene

Alias

Transforming Growth Factor
Beta Receptor III
Betaglycan Proteoglycan
TGFR-3
TGF-Beta Receptor Type 3
TGF-Beta Receptor Type III
Transforming Growth Factor
Beta Receptor III (Betaglycan
300kDa)
BGCAN
betaglycan
Transforming Growth Factor Beta Receptor Type 3
Betaglycan
Transforming Growth Factor Beta Receptor III

Cytogenetic band

NCBI: 1p33-p32 Ensembl: 1p22.1

Protein information

TGBR3_HUMAN

Size: 851 amino acids

Mass: 93499 Da

Subunit: Interacts with TCTEX1D4 Sequence caution: Sequence=AAA67061.1; Type=Frameshift; Positions=70, 73, 349, 350;

Function:

UniProtKB/Swiss-Prot Summary: TGBR3_HUMAN, Q03167 Function: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors

Similarity:

Contains 1 ZP domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001507	ZP_dom	Endoglin/CD105 antigen	Domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	BMP signaling pathway	IDA	GOA	18184661
	cardiac epithelial to mesenchymal transition	IDA	GOA	18184661
	cell growth	ISS	GOA	1333192
	epithelial to mesenchymal transition	IDA	GOA	18184661
	immune response	IMP	GOA	16886151
	intracellular signal transduction	IMP	GOA	14557487
	negative regulation of cellular component movement	IDA	GOA	17999987
	pathway-restricted SMAD protein phosphorylation	IMP	GOA	11157754
	response to follicle-stimulating hormone	IDA	GOA	14557487
	response to luteinizing hormone	IDA	GOA	14557487
	response to prostaglandin E	IDA	GOA	14557487
	transforming growth factor beta receptor signaling pathway	IMP	GOA	11157754
	transforming growth factor beta receptor signaling pathway	IDA	GOA	12958365
Cellular Component	external side of plasma membrane	IDA	GOA	12958365
	extracellular space	TAS	GOA	18184661
	extracellular space	IDA	GOA	16502470
	extracellular vesicular exosome	IDA	GOA	19056867
	inhibin-betaglycan-ActRII complex	IDA	GOA	10746731
Molecular Function	contributes_to protein binding	IPI	GOA	10746731
	coreceptor activity	IDA	GOA	10746731
	glycosaminoglycan binding	TAS	GOA	1333192
	heparin binding	ISS	GOA	1333192
	protein binding	IPI	GOA	10746731
	SMAD binding	IMP	GOA	11157754
	transforming growth factor beta binding	IDA	GOA	11157754
	transforming growth factor beta receptor activity, type III	IDA	GOA	10746731
	transforming growth factor beta receptor binding	ISS	GOA	1333192
	transforming growth factor beta-activated receptor activity	IDA	GOA	12958365
	type II transforming growth factor beta receptor binding	IDA	GOA	11157754

TGFBR3 cross reference