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Subunit: Consists of two polypeptide chains, which are synthesized as a precursor form of a single polypeptide 5 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for TGM3: 1L9M (3D) [IMAGE] 1L9N (3D) [IMAGE] 1NUD (3D) [IMAGE] 1NUF (3D) [IMAGE] 1NUG (3D) [IMAGE]
Function: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath
Catalytic activity: Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3)
Similarity: Belongs to the transglutaminase superfamily. Transglutaminase family [IMAGE]
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