Gene content
Symbol	THPO ( by HUGO)
Name	Thrombopoietin
Category	Oncogene
Alias	thrombopoietin MGDF C-Mpl Ligand Megakaryocyte Colony-Stimulating Factor Megakaryocyte Growth And Development Factor Myeloproliferative Leukemia Virus Oncogene Ligand Megakaryocyte Stimulating Factor MPL Ligand prepro-thrombopoietin ML MPLLG THCYT1 TPO Thrombopoietin Nirs Variant 1 MKCSF
Cytogenetic band	NCBI: 3q27    Ensembl: 3q27.1
Protein information	TPO_HUMAN Size: 353 amino acids Mass: 37823 Da Function: UniProtKB/Swiss-Prot Summary: TPO_HUMAN, P40225 Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets Similarity: Belongs to the EPO/TPO family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR001323	EPO_TPO	Erythropoietin/thrombopoeitin	Family
	IPR003978	Thrombopoeitin	Thrombopoeitin	Family
	IPR009079	4_helix_cytokine-like_core	Four-helical cytokine	Family
	IPR012351	4_helix_cytokine_core	Cytokine, four-helical bundle	Domain
Blocks	IPB003978	Thrombopoietin signature	Thrombopoietin signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	multicellular organismal development	TAS	GOA	8202159
Molecular Function	growth factor activity	TAS	GOA	8202159

Disorder & Mutation
Source	Disease
Genatlas	thrombocythemia,myeloproliferative syndrome due to a sustained proliferation of megakaryocytes,resulting in thrombotic or hemorrhagic episodes and a risk of leukemia

THPO cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene