TAG for THRA

Gene content

Symbol

THRA ( by HUGO)

Name

Thyroid Hormone Receptor, Alpha

Category

Oncogene

Alias

Thyroid Hormone Receptor
Alpha
ERBA1
THRA1
THRA2
Thyroid Hormone Receptor
Alpha (Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog
Avian)
Nuclear Receptor Subfamily 1 Group A Member 1
EAR-7
EAR7
NR1A1
c-erbA-alpha
V-ErbA-Related Protein 7
CHNG6
Thyroid Hormone Receptor
Alpha (Avian Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog)
AR7
ERB-T-1
ERBA
c-ERBA-1
ERBA-Related 7
Thyroid Hormone Receptor Alpha
Thyroid Normone Nuclear Receptor Alpha Variant 1
Triiodothyronine Receptor
c-erbA-1

Cytogenetic band

NCBI: 17q11.2 Ensembl: 17q21.1

Protein information

THA_HUMAN

Size: 490 amino acids

Mass: 54816 Da

Subunit: Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13. Interacts with TP53INP2 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for THRA: 1NAV (3D) [IMAGE] 2H77 (3D) [IMAGE] 2H79 (3D) [IMAGE] 3HZF (3D) [IMAGE] 3ILZ (3D) [IMAGE] 3JZB (3D) [IMAGE]

Function:

UniProtKB/Swiss-Prot Summary: THA_HUMAN, P10827 Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

Similarity:

Belongs to the nuclear hormone receptor family. NR1 subfamily

Contains 1 nuclear receptor DNA-binding domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000536	Nucl_hrmn_rcpt_lig-bd_core	Nuclear hormone receptor, ligand-binding	Domain
	IPR001628	Znf_hrmn_rcpt	Nuclear hormone receptor, DNA-binding	Domain
	IPR001723	Str_hrmn_rcpt	Steroid hormone receptor	Family
	IPR001728	ThyrH_rcpt	Thyroid hormone receptor	Family
	IPR008946	Nucl_hormone_rcpt_ligand-bd	Steroid nuclear receptor, ligand-binding	Domain
Blocks	IPB001723	Steroid hormone receptor signature	Steroid hormone receptor signature
Blocks	IPB001728	Thyroid hormone receptor signature	Thyroid hormone receptor signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	hormone-mediated signaling pathway	IDA	GOA	18052923
	negative regulation of DNA-templated transcription, initiation	IDA	GOA	8524305
	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	IDA	GOA	8524305
	negative regulation of transcription, DNA-templated	IDA	GOA	8710870
	regulation of transcription from RNA polymerase II promoter	IDA	GOA	18052923
	transcription from RNA polymerase II promoter	IDA	GOA	8710870
Cellular Component	cytosol	IDA	GOA	19158403
Cellular Component	nucleus	IDA	GOA	19158403
Molecular Function	protein binding	IPI	GOA	10866662
	protein domain specific binding	IPI	GOA	9653119
	sequence-specific DNA binding transcription factor activity	IDA	GOA	18052923
	TBP-class protein binding	IDA	GOA	8524305
	thyroid hormone binding	IPI	GOA	2879243
	thyroid hormone binding	IDA	GOA	15466465
	thyroid hormone receptor activity	IDA	GOA	15466465
	transcription factor binding	IPI	GOA	8524305
	transcription regulatory region DNA binding	IDA	GOA	18052923

Disorder & Mutation
Source	Disease
Genatlas	hyperthyroxinemia,euthyroidal
SWISS-PROT	Hypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. Note=The disease is caused by mutations affecting the gene represented in this entry

THRA cross reference