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Subunit: Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus) Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for TIAM1 (see all 7): 2D8I (3D) [IMAGE] 3KZD (3D) [IMAGE] 3KZE (3D) [IMAGE] 4GVC (3D) [IMAGE] 4GVD (3D) [IMAGE] 4K2O (3D) [IMAGE]
Tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including TIAM1: Cytoskeleton Regulators in human mouse rat Tight Junctions i
Function: UniProtKB/Swiss-Prot Summary: TIAM1_HUMAN, Q13009 Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration
Similarity: Belongs to the TIAM family Contains 1 DH (DBL-homology) domain Contains 1 PDZ (DHR) domain Contains 2 PH domains Contains 1 RBD (Ras-binding) domain [IMAGE]
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