Gene content    
TNFRSF6B ( by HUGO)
Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy
Oncogene
Tumor Necrosis Factor Receptor Superfamily
Member 6b
Decoy
DCR3
Decoy Receptor 3
Decoy Receptor For Fas Ligand
M68
TR6
DJ583P15.1.1
M68E
Tumor Necrosis Factor Receptor Superfamily Member 6B
DcR3
NCBI: 20q13.3    Ensembl: 20q13.33
TNF6B_HUMANSize: 300 amino acidsMass: 32680 Da

  • Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells [IMAGE] Path
  • Function:
    UniProtKB/Swiss-Prot Summary: TNF6B_HUMAN, O95407 Function: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis
  • Similarity:
    Contains 4 TNFR-Cys repeats [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR001368TNFR/NGFR_Cys_rich_regTNFR/CD27/30/40/95 cysteine-rich regionDomain
    BlocksIPB001368TNFR/CD27/30/40/95 cysteine-rich regionTNFR/CD27/30/40/95 cysteine-rich region

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of apoptotic process TAS GOA 9872321
    Cellular Component extracellular space NAS GOA 10318773
    Molecular Function protein binding IPI GOA 10318773
    receptor activity TAS GOA 9872321

    TNFRSF6B cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene