Gene content
Symbol	TRIM32 ( by HUGO)
Name	Tripartite Motif Containing 32
Category	Oncogene
Alias	Tripartite Motif Containing 32 LGMD2H HT2A Tripartite Motif-Containing 32 Tripartite Motif-Containing Protein 32 Zinc Finger Protein HT2A 72 KDa Tat-Interacting Protein BBS11 Limb Girdle Muscular Dystrophy 2H (Autosomal Recessive) TATIP E3 Ubiquitin-Protein Ligase TRIM32 TAT-Interactive Protein 72-KD Zinc-Finger Protein HT2A EC 6.3.2.-
Cytogenetic band	NCBI: 9q33.1    Ensembl: 9q33.1
Protein information	TRI32_HUMAN Size: 653 amino acids Mass: 71989 Da Subunit: Interacts with DTNBP1. It self-associates 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for TRIM32: 2CT2 (3D) [IMAGE] Tissue specificity: Spleen, thymus, prostate, testis, ovary, intestine, colon and skeletal muscle [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including TRIM32: Ubiquitin Ligases in human mouse rat Primer Products: [IMAGE] OriGene qPCR primer pairs and template s Function: UniProtKB/Swiss-Prot Summary: TRI32_HUMAN, Q13049 Function: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo Enzyme Number (IUBMB): EC 6.3.2.-1 Gene Ontology (GO): Selected molecular function terms (see all 11): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003713 transcription coactivator activity TAS 7778269 GO:0003723 RNA binding ISS -- GO:0004842 ubiquitin-protein ligase activity IDA 16816390 GO:0005515 protein binding IPI 16189514 GO:0008270 zinc ion binding IEA -- [IMAGE] Find genes that share ontologies with TRIM32 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for TRIM32: Increased cell death HMECs cel Similarity: Belongs to the TRIM/RBCC family                        Contains 1 B box-type zinc finger                        Contains 5 NHL repeats                        Contains 1 RING-type zinc finger [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000315	Znf_B-box	Zinc finger, B-box	Domain
	IPR001258	NHL_repeat	NHL repeat	Repeat
	IPR001841	Znf_RING	Zinc finger, RING-type	Domain
	IPR011042	6-blade_b-propeller_TolB-like	TolB, C-terminal	Domain
	IPR013017	NHL_repeat_subgr	NHL	Repeat
Blocks	IPB000315	B-box zinc finger signature	B-box zinc finger signature

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	innate immune response	TAS	GOA	16175175
	innate immune response	IDA	GOA	18248090
	negative regulation of viral transcription	IDA	GOA	18248090
	positive regulation of cell cycle	IDA	GOA	18632609
	positive regulation of cell growth	IDA	GOA	18632609
	positive regulation of cell migration	IDA	GOA	18632609
	positive regulation of proteolysis	IDA	GOA	18632609
	protein polyubiquitination	IDA	GOA	18632609
	protein ubiquitination	IDA	GOA	16816390
	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IMP	GOA	19349376
Cellular Component	cytoplasm	IDA	GOA	19349376
Molecular Function	protein binding	IPI	GOA	16189514
	protein self-association	IDA	GOA	19349376
	Tat protein binding	TAS	GOA	16175175
	transcription coactivator activity	TAS	GOA	7778269
	ubiquitin binding	IDA	GOA	19349376
	ubiquitin-protein transferase activity	IDA	GOA	16816390

Disorder & Mutation
Source	Disease
SWISS-PROT	Limb-girdle muscular dystrophy 2H (LGMD2H) [MIM:254110]: An autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. Note=The disease is caused by mutations affecting the gene represented in this entry

TRIM32 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene