Gene content  |
| TRIO ( by HUGO) |
| Trio Rho Guanine Nucleotide Exchange Factor |
| Oncogene |
| Trio Rho Guanine Nucleotide Exchange Factor Triple Functional Domain (PTPRF Interacting) PTPRF-Interacting Protein EC 2.7.11.1 ARHGEF23 tgat Triple Functional Domain Protein |
| NCBI: 5p15.2 Ensembl: 5p15.2 |
|
Subunit: Interacts to form a complex with leukocyte antigen related protein Sequence caution: Sequence=AAC34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC34245.1; Type=Frameshift; Positions=2301; Sequence=AAC43042.1; Type=Erroneous initiation; 2 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for TRIO: 1NTY (3D) [IMAGE] 2NZ8 (3D) [IMAGE]
Tissue specificity: Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung [IMAGE] Custom PCR Arrays for TRIO Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for TRIO [IMAGE] Pre-validated RT2 qPCR Primer Assay
Function: Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth
Catalytic activity: ATP + a protein = ADP + a phosphoprotein
Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family Contains 1 CRAL-TRIO domain Contains 2 DH (DBL-homology) domains Contains 1 Ig-like C2-type (immunoglobulin-like) domain Contains 2 PH domains Contains 1 protein kinase dom
|
| Protein Domain/Family |
| Source |
ID |
Domain |
Name |
Type |
| InterPro | IPR000219 | DH-domain | DH | Domain
|
| IPR000719 | Prot_kinase_dom | Protein kinase | Domain
|
| IPR001251 | CRAL-TRIO_dom | Cellular retinaldehyde-binding/triple function, C-terminal | Domain
|
| IPR001452 | SH3_domain | SH3 | Domain
|
| IPR001849 | Pleckstrin_homology | Pleckstrin-like | Domain
|
| IPR002017 | Spectrin_repeat | Spectrin repeat | Repeat
|
| IPR002290 | Ser/Thr_dual-sp_kinase_dom | Serine/threonine protein kinase | Domain
|
| IPR003598 | Ig_sub2 | Immunoglobulin C2 type | Domain
|
| IPR007110 | Ig-like_dom | Immunoglobulin-like | Domain
|
| IPR008271 | Ser/Thr_kinase_AS | Serine/threonine protein kinase, active site | Active Sites
|
| IPR011009 | Kinase-like_dom | Protein kinase-like | Domain
|
| IPR011993 | PH_like_dom | Pleckstrin homology-type | Domain
|
| IPR013098 | Ig_I-set | Immunoglobulin I-set | Domain |
| Blocks | IPB000219 | DH domain | DH domain |
| IPB001251 | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) |
| IPB001251 | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) |
| IPB001251 | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) |
| IPB001251 | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) |
| IPB001251 | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) IPB001849 Pleckstrin-like IPB013098 Immunoglobulin I-set | Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO) |
| IPB002017 | Spectrin repeat | Spectrin repeat |
| IPB003598 | Immunoglobulin C-2 type | Immunoglobulin C-2 type |
| IPB011511 | Variant SH3 | Variant SH3 |
