Gene content    
TSPY1 ( by HUGO)
Testis Specific Protein, Y-Linked 1
Oncogene
Testis Specific Protein
Y-Linked 1
TSPY
Cancer/Testis Antigen 78
CT78
Testis Specific Protein
Y-Linked
DYS14
pJA923
Testis-Specific Y-Encoded Protein 1
NCBI: Yp11.2    Ensembl: Yp11.2
TSPY1_HUMANSize: 308 amino acidsMass: 35012 Da

  • Tissue specificity: Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell li
  • Function:
    UniProtKB/Swiss-Prot Summary: TSPY1_HUMAN, Q01534 Function: May be involved in sperm differentiation and proliferation
  • Similarity:
    Belongs to the nucleosome assembly protein (NAP) family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR002164NAP_familyNucleosome assembly protein (NAP)Family
    BlocksIPB002164Nucleosome assembly protein (NAP)Nucleosome assembly protein (NAP)

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell proliferation TAS GOA 8923009
    sex differentiation TAS GOA 1284595
    Molecular Function protein binding IPI GOA 18649364

    Disorder & Mutation    
    Source Disease
    SWISS-PROTNote=TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland

    TSPY1 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene