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Subunit: Interacts with RB1 (both dephosphorylated and hypophosphorylated forms). Interacts with ADORA2A (via cytoplasmic C-terminus); the interaction is direct. Interacts with RB1, RBL1 and RBL2 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for USP4: 2Y6E (3D) [IMAGE]
Tissue specificity: Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons [IMAGE] Custom PCR Arrays for USP4 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mo
Function: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Similarity: Belongs to the peptidase C19 family. USP4 subfamily Contains 1 DUSP domain Contains 2 ubiquitin-like domains Contains 1 USP domain [IMAGE]
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