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Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2. Interacts with HCK (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK. Interacts with PTK2B/PYK2. Interacts (via SH2 domain) with SYK. Interacts with ANKRD54 (By similarity) Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet Sequence caution: Sequence=BAG62721.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355; 6 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for VAV1: 2CRH (3D) [IMAGE] 2LCT (3D) [IMAGE] 2MC1 (3D) [IMAGE] 2ROR (3D) [IMAGE] 3BJI (3D) [IMAGE] 3KY9 (3D) [IMAGE]
Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including VAV1: Focal Adhesions in human mouse rat T-cell & B-cell Activation in human mouse rat Hematopoiesis in human mouse rat
Function: UniProtKB/Swiss-Prot Summary: VAV_HUMAN, P15498 Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation
Similarity: Contains 1 CH (calponin-homology) domain Contains 1 DH (DBL-homology) domain Contains 1 PH domain Contains 1 phorbol-ester/DAG-type zinc finger Contains 1 SH2 domain Contains 2 SH3 domains [IMAGE]
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