Gene content
Symbol	VAV2 ( by HUGO)
Name	Vav
Category	Oncogene
Alias	Vav 2 Guanine Nucleotide Exchange Factor Vav 2 Oncogene VAV-2 Guanine Nucleotide Exchange Factor VAV2
Cytogenetic band	NCBI: 9q34.1    Ensembl: 9q34.2
Protein information	VAV2_HUMAN Size: 878 amino acids Mass: 101289 Da Subunit: Interacts (via SH2 domains) with the phosphorylated form of EPHA2. Interacts with SSX2IP (By similarity). Interacts with NEK3 and PRLR and this interaction is prolactin-dependent 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for VAV2: 2DLZ (3D) [IMAGE] 2DM1 (3D) [IMAGE] 2LNW (3D) [IMAGE] 2LNX (3D) [IMAGE] Tissue specificity: Widely expressed [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including VAV2: Focal Adhesions in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for VAV2 [IMAGE] Pre-validated RT2 qPCR Primer Assay in h Function: UniProtKB/Swiss-Prot Summary: VAV2_HUMAN, P52735 Function: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity) Similarity: Contains 1 CH (calponin-homology) domain                        Contains 1 DH (DBL-homology) domain                        Contains 1 PH domain                        Contains 1 phorbol-ester/DAG-type zinc finger                        Contains 1 SH2 domain                        Contains 2 SH3 domains [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000219	DH-domain	DH	Domain
	IPR000980	SH2	SH2 motif	Domain
	IPR001331	GDS_CDC24_CS	Guanine-nucleotide dissociation stimulator, CDC24	Domain
	IPR001452	SH3_domain	SH3	Domain
	IPR001715	CH-domain	Calponin-like actin-binding	Domain
	IPR001849	Pleckstrin_homology	Pleckstrin-like	Domain
	IPR002219	Prot_Kinase_C-like_PE/DAG-bd	Protein kinase C, phorbol ester/diacylglycerol binding	Domain
	IPR011511	SH3_2	Variant SH3	Domain
	IPR011993	PH_like_dom	Pleckstrin homology-type	Domain
Blocks	IPB000219	DH domain	DH domain
	IPB000980	SH2 domain signature	SH2 domain signature
	IPB001452	SH3 domain signature	SH3 domain signature
	IPB001715	Calponin-like actin-binding	Calponin-like actin-binding
	IPB001849	Pleckstrin-like	Pleckstrin-like
	IPB011511	Variant SH3	Variant SH3

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	signal transduction	TAS	GOA	7762982
Molecular Function	protein binding	IPI	GOA	11390470

VAV2 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene