|
Subunit: Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity) Sequence caution: Sequence=AAC63102.1; Type=Erroneous initiation; Sequence=AAC63143.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAC19512.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Sequence=CAC19516.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon; Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for VEGFA (see all 28): 1BJ1 (3D) [IMAGE] 1CZ8 (3D) [IMAGE] 1FLT (3D) [IMAGE] 1KAT (3D) [IMAGE] 1KMX (3D) [IMAGE] 1MJV (3D) [IMAGE]
Tissue specificity: Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including VEGFA (see all 42): Neurogenesis in human mouse rat
Function: UniProtKB/Swiss-Prot Summary: VEGFA_HUMAN, P15692 Function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth
Similarity: Belongs to the PDGF/VEGF growth factor family [IMAGE]
|
