Gene content    
VPS53 ( by HUGO)
Vacuolar Protein Sorting 53 Homolog (S. Cerevisiae)
Tumor suppressor gene
Vacuolar Protein Sorting 53 Homolog (S. Cerevisiae)
Vacuolar Protein Sorting 53 (Yeast)
HCCS1
hVps53L
pp13624
Vacuolar Protein Sorting-Associated Protein 53 Homolog
NCBI: 17p13.3    Ensembl: 17p13.3
VPS53_HUMANSize: 699 amino acidsMass: 79653 Da

  • Subunit: Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 Sequence caution: Sequence=AAL55842.1; Type=Frameshift; Positions=562;
  • Function:
    UniProtKB/Swiss-Prot Summary: VPS53_HUMAN, Q5VIR6 Function: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD Gene Ontology (GO): 1 molecular function term: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI -- [IMAGE] Find genes that share ontologies with VPS53 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for VPS53: Decreased p24 protein expressi Synthetic lethal with Ras
  • Similarity:
    Belongs to the VPS53 family [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007234Vps53_NVps53-like, N-terminalDomain
    BlocksIPB007234Vps53-likeVps53-like, N-terminal

    Gene Ontology    
    Type Term Evidence Source Pub
    Cellular Component GARP complex IDA GOA 19620288

    VPS53 cross reference    
    PubMed Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene