Gene content  |
| WHSC1 ( by HUGO) |
| Wolf-Hirschhorn Syndrome Candidate 1 |
| Oncogene |
| Wolf-Hirschhorn Syndrome Candidate 1 Nuclear SET Domain-Containing Protein 2 MMSET NSD2 TRX5 EC 2.1.1.43 REIIBP WHS Histone-Lysine N-Methyltransferase NSD2 IL5 Promoter REII Region-Binding Protein Multiple Myeloma SET Domain Containing Protein Type III Probable Histone-Lysine N-Methyltransferase NSD2 Trithorax/Ash1-Related Protein 5 KIAA1090 Multiple Myeloma SET Domain-Containing Protein Protein Trithorax-5 Wolf-Hirschhorn Syndrome Candidate 1 Protein |
| NCBI: 4p16.3 Ensembl: 4p16.3 |
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Tissue specificity: Widely expressed [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including WHSC1: Epigenetic Chromatin Modification Enzymes in human mouse rat Ubiquitin Ligases in human mouse rat Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human
Function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment
Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily Contains 1 AWS domain Contains 1 HMG box DNA-binding domain Contains 4 PHD-type zinc fingers Contains 1 post-SET domain Con
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