Gene content
Symbol	WISP1 ( by HUGO)
Name	WNT1 Inducible Signaling Pathway Protein 1
Category	Oncogene
Alias	WNT1 Inducible Signaling Pathway Protein 1 CCN4 CCN Family Member 4 CTC-458A3.8 WISP1c WISP1i WISP1tc Wnt-1 Inducible Signaling Pathway Protein 1 WNT1 Induced Secreted Protein 1 WNT1-Inducible-Signaling Pathway Protein 1 WISP-1 Wnt-1-Induced Secreted Protein
Cytogenetic band	NCBI: 8q24.22    Ensembl: 8q24.22
Protein information	WISP1_HUMAN Size: 367 amino acids Mass: 40331 Da Tissue specificity: Expressed in heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. Isoform 2 is expressed predominantly in scirrhous gastric carcinoma and, weakly in placenta. Overexpression is associated with several cancers including breast cancer Function: UniProtKB/Swiss-Prot Summary: WISP1_HUMAN, O95388 Function: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan Similarity: Belongs to the CCN family                        Contains 1 CTCK (C-terminal cystine knot-like) domain                        Contains 1 IGFBP N-terminal domain                        Contains 1 TSP type-1 domain                        Contains 1 VWFC domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000867	IGFBP-like	Insulin-like growth factor-binding protein, IGFBP	Domain
	IPR000884	Thrombospondin_1_rpt	Thrombospondin, type I	Repeat
	IPR001007	VWF_C	von Willebrand factor, type C	Domain
	IPR006207	Cys_knot_C	Cystine knot, C-terminal	Domain
	IPR006208	Cys_knot	Cystine knot	Domain
	IPR009030	Growth_fac_rcpt_N_dom	Growth factor, receptor	Domain
	IPR012395	IGFBP_CNN	IGFBP-related, CNN	Family
Blocks	IPB000867	Insulin-like growth factor-binding protein	Insulin-like growth factor-binding protein, IGFBP
	IPB000884	Thrombospondin	Thrombospondin, type I
	IPB001007	von Willebrand factor	von Willebrand factor, type C
	IPB006207	Cystine knot	Cystine knot, C-terminal
	IPB006208	Cystine knot domain	Cystine knot domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell-cell signaling	TAS	GOA	9843955
	signal transduction	TAS	GOA	9843955
Cellular Component	extracellular space	NAS	GOA	9843955

WISP1 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene