Gene content    
WISP2 ( by HUGO)
WNT1 Inducible Signaling Pathway Protein
Oncogene
WNT1 Inducible Signaling Pathway Protein 2
Connective Tissue Growth Factor-Like Protein
Connective Tissue Growth Factor-Related Protein 58
CCN5
CT58
CTGF-L
WISP-2
CCN Family Member 5
Wnt-1 Signaling Pathway Protein 2
WNT1-Inducible-Signaling Pathway Protein 2
CTGFL
NCBI: 20q13.12    Ensembl: 20q13.12
WISP2_HUMANSize: 250 amino acidsMass: 26825 Da

  • Tissue specificity: Expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including WISP2: Estrogen Receptor Signaling in human mouse rat WNT Signaling Targets in human mouse rat Primer Products: [IM
  • Function:
    UniProtKB/Swiss-Prot Summary: WISP2_HUMAN, O76076 Function: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production
  • Similarity:
    Belongs to the CCN family
                          
    Contains 1 IGFBP N-terminal domain
                          
    Contains 1 TSP type-1 domain
                          
    Contains 1 VWFC domain [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR000867IGFBP-likeInsulin-like growth factor-binding protein, IGFBPDomain
    IPR000884Thrombospondin_1_rptThrombospondin, type IRepeat
    IPR001007VWF_Cvon Willebrand factor, type CDomain
    IPR009030Growth_fac_rcpt_N_domGrowth factor, receptorDomain
    BlocksIPB000884ThrombospondinThrombospondin, type I
    IPB001007von Willebrand factorvon Willebrand factor, type C

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process cell-cell signaling TAS GOA 9843955
    signal transduction TAS GOA 9843955
    Cellular Component extracellular space IDA GOA 10358067

    WISP2 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene