Gene content
Symbol	WISP3 ( by HUGO)
Name	WNT1 Inducible Signaling Pathway Protein 3
Category	Oncogene
Alias	WNT1 Inducible Signaling Pathway Protein 3 CCN6 WISP-3 CCN Family Member 6 PPAC PPD LIBC WNT1-Inducible-Signaling Pathway Protein 3
Cytogenetic band	NCBI: 6q21    Ensembl: 6q21
Protein information	WISP3_HUMAN Size: 354 amino acids Mass: 39293 Da Tissue specificity: Predominant expression in adult kidney and testis and fetal kidney. Weaker expression found in placenta, ovary, prostate and small intestine. Also expressed in skeletally-derived cells such as synoviocytes and articular cartilage chondrocytes [IMAGE] Cust Function: UniProtKB/Swiss-Prot Summary: WISP3_HUMAN, O95389 Function: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis Similarity: Belongs to the CCN family                        Contains 1 CTCK (C-terminal cystine knot-like) domain                        Contains 1 IGFBP N-terminal domain                        Contains 1 TSP type-1 domain [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR000867	IGFBP-like	Insulin-like growth factor-binding protein, IGFBP	Domain
	IPR000884	Thrombospondin_1_rpt	Thrombospondin, type I	Repeat
	IPR006207	Cys_knot_C	Cystine knot, C-terminal	Domain
	IPR006208	Cys_knot	Cystine knot	Domain
	IPR009030	Growth_fac_rcpt_N_dom	Growth factor, receptor	Domain
	IPR012395	IGFBP_CNN	IGFBP-related, CNN	Family
Blocks	IPB006207	Cystine knot	Cystine knot, C-terminal
	IPB006208	Cystine knot domain	Cystine knot domain

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	cell-cell signaling	TAS	GOA	9843955
	signal transduction	TAS	GOA	9843955
Cellular Component	extracellular space	NAS	GOA	9843955

Disorder & Mutation
Source	Disease
SWISS-PROT	Progressive pseudorheumatoid arthropathy of childhood (PPAC) [MIM:208230]: Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Note=The disease is caused by mutations affecting the gene represented in this entry

WISP3 cross reference
PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene