TAG for WNT10B

Gene content

Symbol

WNT10B ( by HUGO)

Name

Wingless-Type MMTV Integration Site Family, Member 10B

Category

Other

Alias

Wingless-Type MMTV Integration Site Family
Member 10B
SHFM6
WNT-12
Protein Wnt-10b
WNT-10B Protein
WNT12
Protein Wnt-12

Cytogenetic band

NCBI: 12q13 Ensembl: 12q13.12

Protein information

WN10B_HUMAN

Size: 389 amino acids

Mass: 43000 Da

Tissue specificity: Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Arrays including WNT10B: Hedgehog Signaling Pathway in human mouse rat WNT Signaling P

Function:

UniProtKB/Swiss-Prot Summary: WN10B_HUMAN, O00744 Function: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)

Similarity:

Belongs to the Wnt family [IMAGE]

Protein Domain/Family
Source	ID	Domain	Name	Type
InterPro	IPR005817	Wnt	Wnt superfamily	Family
Blocks	IPB005816	Secreted growth factor Wnt protein	Secreted growth factor Wnt protein

Gene Ontology
Type	Term	Evidence	Source	Pub
Biological Process	canonical Wnt signaling pathway	IDA	GOA	17761539
	chondrocyte differentiation	IEP	GOA	15135146
	hematopoietic stem cell proliferation	IDA	GOA	9787155
	negative regulation of fat cell differentiation	IDA	GOA	10937998
	positive regulation of apoptotic process	IMP	GOA	17761539
	protein stabilization	IDA	GOA	10937998
	Wnt signaling pathway	IMP	GOA	15135146
Cellular Component	extracellular space	NAS	GOA	15135146
Molecular Function	receptor agonist activity	IC	GOA	17761539

Disorder & Mutation
Source	Disease
SWISS-PROT	Split-hand/foot malformation 6 (SHFM6) [MIM:225300]: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Note=The disease is caused by mutations affecting the gene represented in this entry

WNT10B cross reference