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Subunit: Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207 Sequence caution: Sequence=AAP94227.1; Type=Frameshift; Positions=362; 1 PDB 3D structure from [IMAGE] and Proteopedia [IMAGE] for WWOX: 1WMV (3D) [IMAGE]
Tissue specificity: Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines [IMAGE] Pathway & Disease-focused RT2 Profiler PCR Array including WWOX: Oncogenes &
Function: UniProtKB/Swiss-Prot Summary: WWOX_HUMAN, Q9NZC7 Function: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm Enzyme Numbers (IUBMB): EC 1.1.12 EC 1.1.1.-1 Gene Ontology (GO): Selected molecular function terms (see all 6): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding IPI 15064722 GO:0016491 oxidoreductase activity TAS 10786676 GO:0019899 enzyme binding IPI 19366691 GO:0046983 protein dimerization activity TAS 10786676 GO:0048037 cofactor binding TAS 10786676 [IMAGE] Find genes that share ontologies with WWOX About GenesLikeMe Phenotypes: 5 GenomeRNAi human phenotypes for WWOX: Decreased viability with cispl Increased cell death HMECs cel Increased cell death in breast Increased cilium length after Increased gamma-H2AX phosphory
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family Contains 2 WW domains [IMAGE]
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