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Subunit: Component of numerous complexes with chromatin remodeling and histone acetyltransferase activity. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. YEATS4 interacts with MLLT10/AF10. YEATS4 may also interact with the SWI/SNF component SMARCB1/BAF47, TACC1 and TACC2, and the nuclear matrix protein NUMA1 Sequence caution: Sequence=CAC01935.1; Type=Erroneous initiation;
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle [IMAGE] Custom PCR Arrays for YEATS4 Primer Products: [IMAGE] OriGene qPCR primer pairs and template standards for YEATS4 OriGene qSTAR qPCR primer pairs in human, mous
Function: UniProtKB/Swiss-Prot Summary: YETS4_HUMAN, O95619 Function: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding TAS 9302258 GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9302258 GO:0005200 structural constituent of cytoskeleton NAS 10913114 GO:0005515 protein binding IPI 11903063 GO:0008022 protein C-terminus binding IPI 10913114 [IMAGE] Find genes that share ontologies with YEATS4 About GenesLikeMe Phenotypes: 2 GenomeRNAi human phenotypes for YEATS4: Decreased Hepatitis C virus re Increased HPV18 LCR reporter a Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for YEATS4 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for YEATS4 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for YEATS4 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for YEATS4 miRNA Products: [IMAGE] Block miRNA regulation of human, mouse, rat YEATS4 using miScript Target Protectors [IMAGE] 3 qRT-PCR Assays for microRNAs that regulate YEATS4: hsa-miR-218 hsa-miR-3941 hsa-miR-636 [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: YEATS4 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for YEATS4 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat YEATS4 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for YEATS4 Clone Products: [IMAGE] OriGene clones in human, mouse for YEATS4 (see all 7) OriGene ORF clones in mouse, rat for YEATS4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector: YEATS4 (NM_006530) [IMAGE] Sino Biological Human cDNA Clone for YEATS4 [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for YEATS4 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat YEATS4 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for YEATS4 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for YEATS4 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for YEATS4
Similarity: Contains 1 YEATS domain [IMAGE]
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