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Subunit: Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Interacts (via the C-terminal zinc fingers) with GIF1; the interaction results in the recruitment of MYB to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with MYC (via the C-terminal helix-loop-helix motif); the interaction inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest Selected PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ZBTB17 (see all 8): 2LVR (3D) [IMAGE] 2LVT (3D) [IMAGE] 2LVU (3D) [IMAGE] 2M0D (3D) [IMAGE] 2M0E (3D) [IMAGE] 2M0F (3D) [IMAGE]
Tissue specificity: Expressed in germinal center B-cells [IMAGE] Custom PCR Arrays for ZBTB17 Primer Products: [IMAGE] OriGene qSTAR qPCR primer pairs in human, mouse for ZBTB17 [IMAGE] Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZBTB17 [IMAGE] QuantiTect SYBR G
Function: UniProtKB/Swiss-Prot Summary: ZBT17_HUMAN, Q13105 Function: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003676 nucleic acid binding -- -- GO:0003677 DNA binding IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity IDA 12244100 GO:0005515 protein binding IPI 12244100 GO:0046872 metal ion binding IEA -- [IMAGE] Find genes that share ontologies with ZBTB17 About GenesLikeMe Phenotypes:
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family Contains 1 BTB (POZ) domain Contains 13 C2H2-type zinc fingers [IMAGE]
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