Gene content  |
| ZFP36L2 ( by HUGO) |
| ZFP36 Ring Finger Protein-Like |
| Other |
| ZFP36 Ring Finger Protein-Like 2 BRF2 ERF2 TIS11D Zinc Finger Protein 36 C3H Type-Like 1 Zinc Finger Protein 36 C3H Type-Like 2 Butyrate Response Factor 2 ERF-2 RNF162C EGF-Response Factor 2 ZFP36-Like 2 Zinc Finger Protein 36 C3H1 Type-Like 2 Zinc Finger Protein C3H Type 36-Like 2 Protein TIS11D |
| NCBI: 2p22.3-p21 Ensembl: 2p21 |
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Function: UniProtKB/Swiss-Prot Summary: TISD_HUMAN, P47974 Function: mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity) Gene Ontology (GO): Selected molecular function terms (see all 6): About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity TAS 7835719 GO:0017091 AU-rich element binding IDA -- GO:0035925 mRNA 3'-UTR AU-rich region binding IEA -- GO:0044822 poly(A) RNA binding IDA -- [IMAGE] Find genes that share ontologies with ZFP36L2 About GenesLikeMe Phenotypes:
Similarity: Contains 2 C3H1-type zinc fingers [IMAGE]
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