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Subunit: Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I. Interacts with the telomeric protein TERF2IP
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary
Function: Genatlas biochemistry entry for ZNF146: only zinc finger protein 145,(C2H2 type),Kruppel-like,expressed in liver,skeletal muscle,mammary cells,amplified or overexpressed in pancreatic carcinoma and contributing to the progression of tumour Gene Ontology (GO): 5 molecular function terms: About this table GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity IBA -- GO:0008201 heparin binding TAS 8665923 GO:0008270 zinc ion binding TAS 8665923 GO:0046872 metal ion binding -- -- [IMAGE] Find genes that share ontologies with ZNF146 About GenesLikeMe Phenotypes: 1 GenomeRNAi human phenotype for ZNF146: Synthetic lethal with c-Myc af Animal Models: [IMAGE] inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF146 [IMAGE] inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ZNF146 [IMAGE] genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ZNF146 [IMAGE] genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ZNF146 miRNA Products: miRTarBase miRNAs that target ZNF146: hsa-mir-615-3p (MIRT039766), hsa-mir-30c-5p (MIRT048005), hsa-mir-149-5p (MIRT045667) [IMAGE] Block miRNA regulation of human, mouse, rat ZNF146 using miScript Target Protectors [IMAGE] Selected qRT-PCR Assays for microRNAs that regulate ZNF146 (see all 28): hsa-miR-607 hsa-miR-548k hsa-miR-513a-5p hsa-miR-1278 hsa-miR-885-5p hsa-miR-511 hsa-miR-641 hsa-miR-3613-3p [IMAGE] SwitchGear 3'UTR luciferase reporter plasmid: ZNF146 3' UTR sequence Inhib. RNA Products: [IMAGE] OriGene RNAi products in human, mouse, rat for ZNF146 [IMAGE] Predesigned siRNA for gene silencing in human, mouse, rat ZNF146 Gene Editing Products: [IMAGE] DNA2.0 Custom Protein Engineering Service for ZNF146 Clone Products: [IMAGE] OriGene clones in human, mouse for ZNF146 (see all 14) OriGene ORF clones in mouse, rat for ZNF146 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling [IMAGE] GenScript: all cDNA clones in your preferred vector (see all 3): ZNF146 (NM_007145) [IMAGE] Browse Sino Biological Human cDNA Clones [IMAGE] DNA2.0 Custom Codon Optimized Gene Synthesis Service for ZNF146 [IMAGE] Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF146 Cell Line Products: [IMAGE] GenScript Custom overexpressing Cell Line Services for ZNF146 [IMAGE] Browse ESI BIO Cell Lines and PureStem Progenitors for ZNF146 [IMAGE] In Situ Assay Products: [IMAGE] Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF146
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family Contains 10 C2H2-type zinc fingers [IMAGE]
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