Gene content    
ZNF217 ( by HUGO)
Zinc Finger Protein
Oncogene
Zinc Finger Protein 217
ZABC1
NCBI: 20q13.2    Ensembl: 20q13.2
ZN217_HUMANSize: 1048 amino acidsMass: 115272 Da

  • Subunit: Component of a histone deacetylase complex that contains HDAC2, KDM1A, CTBP1 and ZNF217. May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with CTBP1 and CTBP2 4 PDB 3D structures from [IMAGE] and Proteopedia [IMAGE] for ZNF217: 2HU2 (3D) [IMAGE] 3UK3 (3D) [IMAGE] 4F2J (3D) [IMAGE] 4IS1 (3D) [IMAGE]
  • Function:
    UniProtKB/Swiss-Prot Summary: ZN217_HUMAN, O75362 Function: Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'
  • Similarity:
    Belongs to the krueppel C2H2-type zinc-finger protein family
                          
    Contains 7 C2H2-type zinc fingers [IMAGE]

    • Protein Domain/Family    
    Source ID Domain Name Type
    InterProIPR007087Znf_C2H2Zinc finger, C2H2-typeDomain
    BlocksIPB007086C2H2-type zinc finger signatureC2H2-type zinc finger signature

    Gene Ontology    
    Type Term Evidence Source Pub
    Biological Process negative regulation of transcription, DNA-templated IDA GOA 16940172
    regulation of transcription, DNA-templated IDA GOA 18625718
    Cellular Component histone deacetylase complex IDA GOA 18625718
    nucleoplasm IDA GOA 18625718
    Molecular Function protein binding IPI GOA 16940172
    sequence-specific DNA binding transcription factor activity TAS GOA 9671742
    transcription regulatory region DNA binding IDA GOA 18625718

    ZNF217 cross reference    
    PubMed OMIM Entrez Gene NCKU SNP Nucleotide UniProt Genome Data Viewer HomoloGene