Shaw-Jenq Tsai Lab

NCKU, Department of Physiology

Publication

  1. Chen PS, Chiu WT, Hsu PL, Lin SC, Peng IC, Wang CY, *Tsai SJ Pathophysiological implications of hypoxia in human diseases. J Biomed Sci. 2020 11;27(1):63. PMID: 32389123
  2. Wang, C. A., Chang, I H., Hou, P. C., Tai, Y. J., Li, W. N., Hsu, P. L., Wu, S. R., Chiu, W. T., Li, C. F., Shan, Y. S. and *Tsai, S. J. DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancerearly dissemination. Journal of Extracellular Vesicles 2020, 9, (1) PMID: 32341770
  3. Wu, M.H., Hsiao, K.Y., and *Tsai, S. J. Hypoxia: The force of endometriosis. Obstet Gynaecol Re 2019, 45, (3), pp. 532-541 PMID: 30618168
  4. Lin, S.C., Lee, H.C., Hsu, C.T., Huang, Y.H., Li, W.N., Hsu, P.L., Wu, M.H., and *Tsai, S.J.: ‘Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression’, Theranostics, 2019, 9, (3), pp. 620-632 PMID: 30809297
  5. Hsu, P.L., Jou, J., and *Tsai, S.J.: ‘TYRO3: A potential therapeutic target in cancer’, Exp Biol Med (Maywood), 2019, 244, (2), pp. 83-99 PMID: 30714403
  6. Chen, T.M., Lai, M.C., Li, Y.H., Chan, Y.L., Wu, C.H., Wang, Y.M., Chien, C.W., Huang, S.Y., Sun, H.S., and *Tsai, S.J.: ‘hnRNPM induces translation switch under hypoxia to promote colon cancer development’, EBioMedicine, 2019 PMID: 30852162
  7. Chen, T.M., Chen, Y.H., Sun, H.S., and *Tsai, S.J.Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis, Chinese Journal of Physiology2019 62 (1) DOI: 10.4103/CJP.CJP_11_19
  8. Lee, H.C., Lin, S.C., Wu, M.H., and *Tsai, S.J.: ‘Induction of Pyruvate Dehydrogenase Kinase 1 by Hypoxia Alters Cellular Metabolism and Inhibits Apoptosis in Endometriotic Stromal Cells’, Reprod Sci, 2018, pp. 1933719118789513 PMID: 30092712
  9. Fu, J.L., Hsiao, K.Y., Lee, H.C., Li, W.N., Chang, N., Wu, M.H., and *Tsai, S.J.: ‘Suppression of COUP-TFII upregulates angiogenin and promotes angiogenesis in endometriosis’, Human Reproduction, 2018, 33, (8), pp. 1517-1527 PMID: 29982401
  10. Li, W.N., Wu, M.H., and *Tsai, S.J.Critical Factors Involved in Chronic Inflammation in the Pathophysiology of Endometriosis Adaptive Medicine2018 10(1): 1-9, DOI: 10.4247/AM.2018.ABI197
  11. Brown, D.M., Lee, H.C., Liu, S., Quick, C.M., Fernandes, L.M., Simmen, F.A., Tsai, S.J., and Simmen, R.C.M.: ‘Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis’, J Endocr Soc, 2018, 2, (7), pp. 765-778 PMID: 30151432
  12. Hou, P. C., Li, Y. H., Lin, S. C., Lin, S. C., Lee, J. C., Lin, B. W., Liou, J. P., Chang, J. Y., Kuo, C. C., Liu, Y. M., Sun, H. S., and *Tsai, S. J.(2017) Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. Cancer research77, 4305-4316 PMID: 28652251
  13. Lin, S. C., Lee, H. C., Hou, P. C., Fu, J. L., Wu, M. H., and *Tsai, S. J.(2017) Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility. Journal of Pathology242, 476-487 PMID: 28608501
  14. Hsiao, K. Y., Lin, Y. C., Gupta, S. K., Chang, N., Yen, L., Sun, H. S., and *Tsai, S. J.(2017) Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Cancer research77, 2339-2350 PMID: 28249903
  15. Lin, S. C., Hsiao, K. Y., Chang, N., Hou, P. C., and *Tsai, S. J.(2017) Loss of dual-specificity phosphatase-2 promotes angiogenesis and metastasis via up-regulation of interleukin-8 in colon cancer. J Pathol241, 638-648 PMID: 28026024
  16. Lin, S. C., Kao, C. Y., Lee, H. J., Creighton, C. J., Ittmann, M. M., Tsai, S. J., Tsai, S. Y., and Tsai, M. J. (2016) Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun7, 11418 PMID: 27108958
  17. Lai, M. S., Wang, C. Y., Yang, S. H., Wu, C. C., Sun, H. S., Tsai, S. J., Chuang, J. I., Chen, Y. C., and Huang, B. M. (2016) The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes. Organogenesis12, 61-77 PMID: 27078042
  18. Chien, C. W., Hou, P. C., Wu, H. C., Chang, Y. L., Lin, S. C., Lin, S. C., Lin, B. W., Lee, J. C., Chang, Y. J., Sun, H. S., and ＊ Tsai, S. J. (2016) Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. OncogenePMID: 27132510
  19. Wang, C. A., and ＊ Tsai, S. J. (2015) The non-canonical role of vascular endothelial growth factor-C axis in cancer progression. Exp Biol Med (Maywood)240, 718-724 PMID: 25888649
  20. Liang, K. C., Tseng, J. T., Tsai, S. J., and Sun, H. S. (2015) Characterization and distribution of repetitive elements in association with genes in the human genome. Comput Biol Chem57, 29-38 PMID: 25748288
  21. Hsiao, K. Y., Wu, M. H., Chang, N., Yang, S. H., Wu, C. W., Sun, H. S., and ＊ Tsai, S. J. (2015) Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis. Mol Hum Reprod21, 894-904 PMID: 26433194
  22. Hsiao, K. Y., Lin, S. C., ＊ Wu, M. H., and ＊ Tsai, S. J. (2015) Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed)7, 309-321 PMID: 25553382
  23. Fu, M. H., Li, C. L., Lin, H. L., Tsai, S. J., Lai, Y. Y., Chang, Y. F., Cheng, P. H., Chen, C. M., and Yang, S. H. (2015) The Potential Regulatory Mechanisms of miR-196a in Huntington's Disease through Bioinformatic Analyses. PLoS One10, e0137637 PMID: 26376480
  24. Chuang, J. I., Huang, J. Y., Tsai, S. J., Sun, H. S., Yang, S. H., Chuang, P. C., Huang, B. M., and Ching, C. H. (2015) FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation. Free Radic Biol Med89, 274-286 PMID: 26424114
  25. Tang, Y. T., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2014) A semi-supervised, weighted pattern-learning approach for extraction of gene regulation relationships from scientific literature. Int J Data Min Bioinform9, 401-416 PMID: 25757247
  26. Lin, S. C., Liao, W. L., Lee, J. C., and ＊ Tsai, S. J. (2014) Hypoxia-regulated gene network in drug resistance and cancer progression. Exp Biol Med (Maywood)239, 779-792 PMID: 24812122
  27. Lin, S. C., Li, Y. H., Wu, M. H., Chang, Y. F., Lee, D. K., Tsai, S. Y., Tsai, M. J., and ＊ Tsai, S. J. (2014) Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. J Clin Endocrinol Metab99, E427-437 PMID: 24423359
  28. Liao, W.-L., Lin, S.-C., Sunny Sun, H., and ＊ Tsai, S. J . (2014) Hypoxia-induced tumor malignancy and drug resistance: Role of microRNAs. Biomarkers and Genomic Medicine6, 1-11 http://dx.doi.org/10.1016/j.bgm.2014.01.003
  29. Lai, M. S., Cheng, Y. S., Chen, P. R., Tsai, S. J., and Huang, B. M. (2014) Fibroblast growth factor 9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells. PLoS One9, e90243 PMID: 24603862
  30. Chen, T. M., Shih, Y. H., Tseng, J. T., Lai, M. C., Wu, C. H., Li, Y. H., ＊ Tsai, S. J. , and ＊ Sun, H. S. (2014) Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res42, 2932-2944 PMID: 24334956
  31. Wu, S. P., Cheng, C. M., Lanz, R. B., Wang, T., Respress, J. L., Ather, S., Chen, W., Tsai, S. J., Wehrens, X. H., Tsai, M. J., and Tsai, S. Y. (2013) Atrial identity is determined by a COUP-TFII regulatory network. Developmental cell25, 417-426 http://dx.doi.org/10.1016/j.devcel.2013.04.017
  32. Wu, M. H., Chuang, P. C., Lin, Y. J., and ＊ Tsai, S. J. (2013) Suppression of annexin A2 by prostaglandin E(2) impairs phagocytic ability of peritoneal macrophages in women with endometriosis. Hum Reprod28, 1045-1053 PMID: 23340055
  33. Wang, H. C., Kooi, T. K., Kao, H. Y., Lin, S. C., and Tsai, S. J.(2013) Using positive and negative patterns to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med43, 2214-2221 PMID: 24290938
  34. Qin, J., Wu, S. P., Creighton, C. J., Dai, F., Xie, X., Cheng, C. M., Frolov, A., Ayala, G., Lin, X., Feng, X. H., Ittmann, M. M., Tsai, S. J., Tsai, M. J., and Tsai, S. Y. (2013) COUP-TFII inhibits TGF-beta-induced growth barrier to promote prostate tumorigenesis. Nature493, 236-240 PMID: 23201680
  35. Lai, M. C., Wang, S. W., Cheng, L., Tarn, W. Y., ＊ Tsai, S. J. , and ＊ Sun, H. S. (2013) Human DDX3 interacts with the HIV-1 Tat protein to facilitate viral mRNA translation. PLoS One8, e68665 PMID: 23840900
  36. Cheng, P. H., Li, C. L., Chang, Y. F., Tsai, S. J., Lai, Y. Y., Chan, A. W., Chen, C. M., and Yang, S. H. (2013) miR-196a ameliorates phenotypes of Huntington disease in cell, transgenic mouse, and induced pluripotent stem cell models. Am J Hum Genet93, 306-312 PMID: 23810380
  37. Chen, J. S., Hung, W. S., Chan, H. H., Tsai, S. J., and Sun, H. S. (2013) In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics29, 420-427 PMID: 23267173
  38. Chen, H. M., Lin, Y. H., Cheng, Y. M., Wing, L. Y., and ＊ Tsai, S. J. (2013) Overexpression of integrin-beta1 in leiomyoma promotes cell spreading and proliferation. J Clin Endocrinol Metab98, E837-846 PMID: 23482612

  39. Wu, M. H., Lu, C. W., Chang, F. M., and ＊ Tsai, S. J. (2012) Estrogen receptor expression affected by hypoxia inducible factor-1alpha in stromal cells from patients with endometriosis. Taiwan J Obstet Gynecol51, 50-54 http://dx.doi.org/10.1016/j.tjog.2012.01.010
  40. Wiltbank, M. C., Salih, S. M., Atli, M. O., Luo, W., Bormann, C. L., Ottobre, J. S., Vezina, C. M., Mehta, V., Diaz, F. J., Tsai, S. J., and Sartori, R. (2012) Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants. Animal reproduction / Colegio Brasileiro de Reproducao Animal9, 242-259
  41. Wang, C. C., Lin, S. C., Lee, Y. H., and ＊ Tsai, S.J. (2012) Hypoxia-Induced Tumor Progression and Drug Resistance: From Current Understandings to Future Perspectives. Adaptive Medicine4, 132-144 DOI: 10.4247/AM.2012.ABC033
  42. Lin, S. C., Wang, C. C., Wu, M. H., Yang, S. H., Li, Y. H., and ＊ Tsai, S. J. (2012) Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab97, E1515-1523 PMID: 22648654
  43. Lin, M. W., Tsai, S. J., Chou, P. Y., Huang, M. F., Sun, H. S., and Wu, M. H. (2012) Vitamin D receptor 1a promotor -1521 G/C and -1012 A/G polymorphisms in polycystic ovary syndrome. Taiwan J Obstet Gynecol51, 565-571 http://dx.doi.org/10.1016/j.tjog.2012.09.011
  44. Wu, M. H., Lin, S. C., Hsiao, K. Y., and ＊ Tsai, S. J. (2011) Hypoxia-inhibited dual-specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol225, 390-400 PMID: 21984126
  45. Wang, H. C., Chen, Y. H., Kao, H. Y., and ＊ Tsai, S. J. (2011) Inference of transcriptional regulatory network by bootstrapping patterns. Bioinformatics27, 1422-1428 PMID: 21450714
  46. Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H., Hsiao, S. H., and Leu, Y. W. (2011) Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer research71, 4653-4663 PMID: 21518779
  47. Tang, Y. T., Li, S. J., Kao, H. Y., Tsai, S. J., and Wang, H. C. (2011) Using unsupervised patterns to extract gene regulation relationships for network construction. PLoS One6, e19633 PMID: 21573008
  48. Lu, C. W., Lin, S. C., Chien, C. W., Lin, S. C., Lee, C. T., Lin, B. W., Lee, J. C., and ＊ Tsai, S. J. (2011) Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am J Pathol179, 1405-1414 PMID: 21763680
  49. Lin, Y. S., Tsai, S. J., Lin, M. W., Yang, C. T., Huang, M. F., and Wu, M. H. (2011) Interleukin-6 as an early chronic inflammatory marker in polycystic ovary syndrome with insulin receptor substrate-2 polymorphism. American journal of reproductive immunology (New York, N.Y. : 1989)66, 527-533 PMID: 21801267
  50. Lin, S. C., Chien, C. W., Lee, J. C., Yeh, Y. C., Hsu, K. F., Lai, Y. Y., Lin, S. C., and ＊ Tsai, S. J. (2011) Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest121, 1905-1916 PMID: 21490398
  51. Wu, M. H., Lu, C. W., Chuang, P. C., and ＊ Tsai, S. J. (2010) Prostaglandin E2: the master of endometriosis? Exp Biol Med (Maywood) . 235(6), 668-77 PMID: 20511671
  52. Wu, M. H., Huang, M. F., Chang, F. M., and ＊ Tsai, S. J. (2010) Leptin on peritoneal macrophages of patients with endometriosis. American journal of reproductive immunology (New York, N.Y. : 1989)63, 214-221 PMID: 20047585
  53. Lin, Y. M., Tsai, C. C., Chung, C. L., Chen, P. R., Sun, H. S., ＊ Tsai, S. J. , and ＊ Huang, B. M. (2010) Fibroblast growth factor 9 stimulates steroidogenesis in postnatal Leydig cells. International journal of andrology33, 545-553 PMID: 19508331
  54. Hsiao, S. H., Lee, K. D., Hsu, C. C., Tseng, M. J., Jin, V. X., Sun, W. S., Hung, Y. C., Yeh, K. T., Yan, P. S., Lai, Y. Y., Sun, H. S., Lu, Y. J., Chang, Y. S., Tsai, S. J., Huang, T. H., and Leu, Y. W. (2010) DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination. Biochemical and biophysical research communications400, 305-312 PMID: 20727853
  55. Chuang, P. C., Lin, Y. J., Wu, M. H., Wing, L. Y., Shoji, Y., and ＊ Tsai, S. J. (2010) Inhibition of CD36-dependent phagocytosis by prostaglandin E2 contributes to the development of endometriosis. Am J Pathol176, 850-860 PMID: 20035060
  56. Chen, W., ＊ Tsai, S. J. , Sheu, H. M., Tsai, J. C., and Zouboulis, C. C. (2010) Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone. Experimental dermatology19, 470-472 PMID: 20337700
  57. Chen, T. M., Hsu, C. H., ＊ Tsai, S. J. , and ＊ Sun, H. S. (2010) AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay. Nucleic Acids Res38, 8061-8071 PMID: 20716519
  58. Pan, H. A., Lee, Y. C., Teng, Y. N., Tsai, S. J., Lin, Y. M., and Kuo, P. L. (2009) CDC25 protein expression and interaction with DAZL in human corpus luteum. Fertility and sterility92, 1997-2003 PMID: 19006796
  59. Chuang, P. C., Wu, M. H., Shoji, Y., and ＊ Tsai, S. J. (2009) Downregulation of CD36 results in reduced phagocytic ability of peritoneal macrophages of women with endometriosis. J Pathol219, 232-241 PMID: 19606481
  60. Chen, W., ＊ Tsai, S. J. , Wang, C. A., Tsai, J. C., and Zouboulis, C. C. (2009) Human sebocytes express prostaglandin E2 receptors EP2 and EP4 but treatment with prostaglandin E2 does not affect testosterone production. The British journal of dermatology161, 674-677 PMID: 19438438
  61. Yang, C. Y., Wang, Y. J., Chen, P. C., Tsai, S. J., and Guo, Y. L. (2008) Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental health perspectives116, 599-604 PMID: 18470317
  62. Lu, C. W., Lin, S. C., Chen, K. F., Lai, Y. Y., and ＊ Tsai, S. J. (2008) Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. The Journal of biological chemistry283, 28106-28114 PMID: 18718909
  63. Hsu, C. C., Lu, C. W., Huang, B. M., Wu, M. H., and ＊ Tsai, S. J. (2008) Cyclic adenosine 3',5'-monophosphate response element-binding protein and CCAAT/enhancer-binding protein mediate prostaglandin E2-induced steroidogenic acute regulatory protein expression in endometriotic stromal cells. Am J Pathol173, 433-441 PMID: 18583320
  64. Chien, C. W., Lin, S. C., Lai, Y. Y., Lin, B. W., Lin, S. C., ＊ Lee, J. C., and ＊ Tsai, S. J. (2008) Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research14, 8043-8051 PMID: 19073968
  65. Wu, M. H., Shoji, Y., Chuang, P. C., and ＊ Tsai, S. J. (2007) Endometriosis: disease pathophysiology and the role of prostaglandins. Expert reviews in molecular medicine9, 1-20 PMID: 17227592
  66. Wu, M. H., Chen, K. F., Lin, S. C., Lgu, C. W., and ＊ Tsai, S. J. (2007) Aberrant expression of leptin in human endometriotic stromal cells is induced by elevated levels of hypoxia inducible factor-1alpha. Am J Pathol170, 590-598 PMID: 17255327
  67. Chan, H. H., Tsai, S. T., and Sun, H. S. (2007) TAG: a comprehensive database for cancer research. Nucleic Acids Res Molecular Biology Database Collection, # 922
  68. Chen, W., Yang, C. C., Tsai, R. Y., Liao, C. Y., Yen, Y. T., Hung, C. L., Chen, K. F., Tsai, S. J., and Zouboulis, C. C. (2007) Expression of sex-determining genes in the scalp of men with androgenetic alopecia. Dermatology (Basel, Switzerland)214, 199-204 PMID: 17377380
  69. Chen, T. M., Kuo, P. L., Hsu, C. H., Tsai, S. J., Chen, M. J., Lin, C. W., and Sun, H. S. (2007) Microsatellite in the 3' untranslated region of human fibroblast growth factor 9 (FGF9) gene exhibits pleiotropic effect on modulating FGF9 protein expression. Human mutation28, 98 PMID: 17154280
  70. Chuang, P. C., Sun, H. S., Chen, T. M., and ＊ Tsai, S. J. (2006) Prostaglandin E2 induces fibroblast growth factor 9 via EP3-dependent protein kinase Cdelta and Elk-1 signaling. Molecular and cellular biology26, 8281-8292 PMID: 16982695
  71. Chen, Y. F., Kou, P. L., Tsai, S. J., Chen, K. F., Chan, H. H., Chen, C. M., and Sun, H. S. (2006) Computational analysis and refinement of sequence structure on chromosome 22q11.2 region: application to the development of quantitative real-time PCR assay for clinical diagnosis. Genomics87, 290-297 PMID: 16307865
  72. Chen, W., Yang, C. C., Liao, C. Y., Hung, C. L., Tsai, S. J., Chen, K. F., Sheu, H. M., and Zouboulis, C. C. (2006) Expression of sex-determining genes in human sebaceous glands and their possible role in the pathogenesis of acne. Journal of the European Academy of Dermatology and Venereology : JEADV20, 846-852 PMID: 16898909
  73. Chen, W., Tsai, S. J., Liao, C. Y., Tsai, R. Y., Chen, Y. J., Pan, B. J., Hung, C. L., and Zouboulis, C. C. (2006) Higher levels of steroidogenic acute regulatory protein and type I 3beta-hydroxysteroid dehydrogenase in the scalp of men with androgenetic alopecia. The Journal of investigative dermatology126, 2332-2335 PMID: 16778788
  74. Wu, M. H., Wang, C. A., Lin, C. C., Chen, L. C., Chang, W. C., and ＊ Tsai, S. J. (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab90, 286-295 PMID: 15483103
  75. Wu, M. H., Shoji, Y., Wu, M. C., Chuang, P. C., Lin, C. C., Huang, M. F., and ＊ Tsai, S. J. (2005) Suppression of matrix metalloproteinase-9 by prostaglandin E(2) in peritoneal macrophage is associated with severity of endometriosis. Am J Pathol167, 1061-1069 PMID: 16192641
  76. Wing, L. Y., Chen, H. M., Chuang, P. C., Wu, M. H., and ＊ Tsai, S. J. (2005) The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. The Journal of biological chemistry280, 19937-19947 PMID: 15760907
  77. Tsai, S. J. , Lin, S. J., Cheng, Y. M., Chen, H. M., and Wing, L. Y. (2005) Expression and functional analysis of pituitary tumor transforming gene-1 [corrected] in uterine leiomyomas. J Clin Endocrinol Metab90, 3715-3723 PMID: 15769981
  78. Chen, W., Chen, G. Y., Tsai, S. J., Wang, P. W., Sheu, H. M., Shen, Y. S., and Chen, F. F. (2005) Mild cutaneous manifestation in two young women with extraordinary hyperandrogenemia. Dermatology (Basel, Switzerland)210, 49-52 PMID: 15604546
  79. Chen, K. F., Lai, Y. Y., Sun, H. S., and ＊ Tsai, S. J. (2005) Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha. Nucleic Acids Res33, 5190-5198 PMID: 16155188
  80. Wu, M. H., Huang, M. F., Tsai, S. J., Pan, H. A., Cheng, Y. C., and Lin, Y. S. (2004) Effects of laparoscopic ovarian drilling on young adult women with polycystic ovarian syndrome. The Journal of the American Association of Gynecologic Laparoscopists11, 184-190 PMID: 15200772
  81. Huang, B. M., Hsiao, K. Y., Chuang, P. C., Wu, M. H., Pan, H. A., and ＊ Tsai, S. J. (2004) Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Biology of reproduction70, 1358-1364 PMID: 14711788
  82. Wu, M. H., Tsai, S. J., Pan, H. A., Hsiao, K. Y., and Chang, F. M. (2003) Three-dimensional power Doppler imaging of ovarian stromal blood flow in women with endometriosis undergoing in vitro fertilization. Ultrasound Obstet Gynecol21, 480-485 PMID: 12768561
  83. Wing, L. Y., Chuang, P. C., Wu, M. H., Chen, H. M., and ＊ Tsai, S. J. (2003) Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab88, 5547-5554 PMID: 14602803
  84. Vasconcelos, J. L., Sangsritavong, S., Tsai, S. J., and Wiltbank, M. C. (2003) Acute reduction in serum progesterone concentrations after feed intake in dairy cows. Theriogenology60, 795-807 PMID: 12935858
  85. Sun, H. S., Hsiao, K. Y., Hsu, C. C., Wu, M. H., and ＊ Tsai, S. J. (2003) Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor. Endocrinology144, 3934-3942 PMID: 12933667
  86. Ip, S. P., Wong, T. P., Tsai, S. J., and Leung, P. S. (2003) The recovery of some components of the renin angiotensin system in the rat pancreas after chronic exposure to hypoxic condition. Journal of molecular endocrinology31, 563-571 PMID: 14664716
  87. Hsu, C. C., ＃ Tsai, S. J. , Huang, Y. L., and Huang, B. M. (2003) Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis. FEBS letters543, 140-143 PMID: 12753921
  88. Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. (2003) In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci73, 2127-2136 PMID: 12899935
  89. Yang, A. L., Tsai, S. J., Jiang, M. J., Jen, C. J., and Chen, H. I. (2002) Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta. Journal of biomedical science9, 149-155 PMID: 11914582
  90. Wu, M. H., Sun, H. S., Lin, C. C., Hsiao, K. Y., Chuang, P. C., Pan, H. A., and ＊ Tsai, S. J. (2002) Distinct mechanisms regulate cyclooxygenase-1 and-2 in peritoneal macrophages of women with and without endometriosis. Molecular Human Reproduction8, 1103-1110 PMID: 12468643
  91. Wu, M. H., Chuang, P. C., Chen, H. M., Lin, C. C., and ＊ Tsai, S. J. (2002) Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation. Mol Hum Reprod8, 456-464 PMID: 11994543
  92. Tsai, S. J. , Wu, M. H., Chen, H. M., Chuang, P. C., and Wing, L. Y. (2002) Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology143, 2715-2721 PMID: 12072406
  93. Pan, H. A., Tsai, S. J., Chen, C. W., Lee, Y. C., Lin, Y. M., and Kuo, P. L. (2002) Expression of DAZL protein in the human corpus luteum. Mol Hum Reprod8, 540-545 PMID: 12029071
  94. Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Lin, J. S., and Kuo, P. L. (2002) Presence of DAZL transcript and protein in mature human spermatozoa. Fertility and sterility77, 626-629 PMID: 11872225
  95. Diaz, F. J., Anderson, L. E., Wu, Y. L., Rabot, A., Tsai, S. J., and Wiltbank, M. C. (2002) Regulation of progesterone and prostaglandin F2alpha production in the CL. Molecular and cellular endocrinology191, 65-80 PMID: 12044920
  96. Tsai, S. J. , Wu, M. H., Lin, C. C., Sun, H. S., and Chen, H. M. (2001) Regulation of steroidogenic acute regulatory protein expression and progesterone production in endometriotic stromal cells. J Clin Endocrinol Metab86, 5765-5773 PMID: 11739437
  97. Tsai, S. J. , Wu, M. H., Chuang, P. C., and Chen, H. M. (2001) Distinct regulation of gene expression by prostaglandin F(2alpha) (PGF(2alpha)) is associated with PGF(2alpha) resistance or susceptibility in human granulosa-luteal cells. Mol Hum Reprod7, 415-423 PMID: 11331663
  98. Tsai, S. J. , and Wiltbank, M. C. (2001) Differential effects of prostaglandin F2alpha on in vitro luteinized bovine granulosa cells. Reproduction (Cambridge, England)122, 245-253 PMID: 11467975
  99. Tsai, S. J. , Kot, K., Ginther, O. J., and Wiltbank, M. C. (2001) Temporal gene expression in bovine corpora lutea after treatment with PGF2alpha based on serial biopsies in vivo. Reproduction (Cambridge, England)121, 905-913 PMID: 11373177
  100. Lin, Y. M., Chen, C. W., Sun, H. S., Tsai, S. J., Hsu, C. C., Teng, Y. N., Lin, J. S., and Kuo, P. L. (2001) Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. Mol Hum Reprod7, 1015-1022 PMID: 11675467
  101. Leung, P. S., Tsai, S. J., Wallukat, G., Leung, T. N., and Lau, T. K. (2001) The upregulation of angiotensin II receptor AT(1) in human preeclamptic placenta. Molecular and cellular endocrinology184, 95-102 PMID: 11694345
  102. Huang, B. M., Hsu, C. C., Tsai, S. J., Sheu, C. C., and Leu, S. F. (2001) Effects of Cordyceps sinensis on testosterone production in normal mouse Leydig cells. Life Sci69, 2593-2602 PMID: 11712663
  103. Anderson, L. E., Wu, Y. L., Tsai, S. J., and Wiltbank, M. C. (2001) Prostaglandin F(2alpha) receptor in the corpus luteum: recent information on the gene, messenger ribonucleic acid, and protein. Biology of reproduction64, 1041-1047 PMID: 11259248
  104. Kot, K., Anderson, L. E.,  Tsai, S. J., Wiltbank, M. C., and Ginther, O. J. (1999) Transvaginal, ultrasound-guided biopsy of the corpus luteum in cattle.  Theriogenology 52, 987-993 PMID: 10735106
  105. Tsai, S. J. , and Wiltbank, M. C. (1998) Prostaglandin F2alpha regulates distinct physiological changes in early and mid-cycle bovine corpora lutea.  Biology of reproduction 58, 346-352 PMID: 9475388
  106. Tsai, S. J. , Anderson, L. E., Juengel, J., Niswender, G. D., and Wiltbank, M. C. (1998) Regulation of prostaglandin F2 alpha and E receptor mRNA by prostaglandin F 2 alpha in ovine corpora lutea.  Journal of reproduction and fertility 114, 69-75 PMID: 9875157
  107. Tsai, S. J. , and Wiltbank, M. C. (1997) Prostaglandin F2alpha induces expression of prostaglandin G/H synthase-2 in the ovine corpus luteum: a potential positive feedback loop during luteolysis.  Biology of reproduction 57, 1016-1022 PMID: 9369165
  108. Tsai, S. J. , Juengel, J. L., and Wiltbank, M. C. (1997) Hormonal regulation of monocyte chemoattractant protein-1 messenger ribonucleic acid expression in corpora lutea.  Endocrinology 138, 4517-4520 PMID: 9322976
  109. Burns, P. D.,  Tsai, S. J., Wiltbank, M. C., Hayes, S. H., Graf, G. A., and Silvia, W. J. (1997) Effect of oxytocin on concentrations of prostaglandin H synthase-2 mRNA in ovine endometrial tissue in vivo.  Endocrinology 138, 5637-5640 PMID: 9389552
  110. Tsai, S. J. , Wiltbank, M. C., and Bodensteiner, K. J. (1996) Distinct mechanisms regulate induction of messenger ribonucleic acid for prostaglandin (PG) G/H synthase-2, PGE (EP3) receptor, and PGF2 alpha receptor in bovine preovulatory follicles.  Endocrinology 137, 3348-3355 PMID: 8754761
  111. Tsai, S. J. , and Wiltbank, M. C. (1996) Quantification of mRNA using competitive RT-PCR with standard-curve methodology.  Biotechniques 21, 862-866 PMID: 8922627
  112. Duello, T. M.,  Tsai, S. J., and Van Ess, P. J. (1993) In situ demonstration and characterization of progonadotropin-releasing hormone messenger ribonucleic acid in first trimester human placentas.  Endocrinology 133, 2617-2623 PMID: 8243285
  113. Yuan, C. C., Tsai, L. C., Hsu, S. C., Ng, H. T.,  Tsai, S. J., Chen, H. M., Hung, M. W., Ho, C. K., Ho, D. M., and Gill, T. J., 3rd. (1992) Production and characterisation of a monoclonal antibody (Cx-99) against cervical carcinoma.  Br J Cancer 65, 201-207 PMID: 1739618
  114. Tsai, L. C., Tang, R. B., Hung, M. W., Chen, H. M., and  Tsai, S. J. (1990) Expression of serum IL-2, IL-2R, and CD8 levels during hyposensitization in house-dust-sensitive asthmatics.  J Asthma 27, 307-313 PMID: 2122966
  115. Tsai, L.C., Hung, M. W., Chen, H.M., Chang, Z.N., and  Tsai, S.J. (1989) Measurement of specific IgE antibody in mite-sensitive asthmatic children by enzyme-linked immunosorbent assay.  Chin Med J (Taipei) 44, 352-357
  116. Yuan, C. C., Tsai, L. T.,  Tsai, S. J., Hsu, S. C., Ho, D. M., Chen, H. M., Hung, M. W., Lee, L. C., and Ng, H. T. (1989) Immunohistochemical study of carcinoembryonic antigen in cervical cancer-using a monoclonal antibody Mab C27.  Chin Med J (Taipei) 44, 341-346